HGFR/c-Met Protein, Human, Recombinant (His)

Name: HGFR/c-Met Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01296
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: RCCP2, MET proto-oncogene, receptor tyrosine kinase, HGFR, DFNB97, c-Met, AUTS9) Copy Product Info

Synonyms: RCCP2, MET proto-oncogene, receptor tyrosine kinase, HGFR, DFNB97, c-Met, AUTS9

Catalog No. TMPY-01296 Copy Product Info

HGFR/c-Met Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is A0A024R759.

Pack Size	Price	USA Stock	Global Stock
5 µg	$41	-	In Stock
10 µg	$63	-	In Stock
20 µg	$100	7-10 days	7-10 days
50 µg	$192	-	In Stock
100 µg	$320	-	In Stock
200 µg	$597	7-10 days	7-10 days
500 µg	$1,360	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:SDS-PAGE: 92.4%; SEC-HPLC: 98.0%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Recombinant Human HGF / Hepatocyte Growth Factor Protein at 2μg/mL (100μL/well) can bind Recombinant Human c-MET / HGFR Protein (His Tag) , the EC50 is 16-48 ng/mL.
Description	HGFR/c-Met Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is A0A024R759.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P08581
Construction	A DNA sequence encoding the extracellular domain of human c-Met (NP_000236.2) (Met1-Thr932) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Glu 25
Protein Purity	≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. ,
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 150 mM NaCl, pH8.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	RCCP2, MET proto-oncogene, receptor tyrosine kinase, HGFR, DFNB97, c-Met, AUTS9
Research Background	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

103 kDa (predicted); 45 kDa and 85 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.