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HGFR/c-Met Protein, Human, Recombinant (His & hFc)
(Synonyms: RCCP2, MET proto-oncogene, receptor tyrosine kinase, HGFR, DFNB97, c-Met, AUTS9) Copy Product InfoSynonyms: RCCP2, MET proto-oncogene, receptor tyrosine kinase, HGFR, DFNB97, c-Met, AUTS9
Catalog No. TMPY-00718 Copy Product Info
HGFR/c-Met Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 129.5 kDa and the accession number is A0A024R759.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $48 | 7-10 days | 7-10 days | |
| 10 µg | $76 | 7-10 days | 7-10 days | |
| 20 µg | $118 | 7-10 days | 7-10 days | |
| 50 µg | $237 | 7-10 days | 7-10 days | |
| 100 µg | $458 | 7-10 days | 7-10 days | |
| 200 µg | $693 | 7-10 days | 7-10 days | |
| 500 µg | $1,450 | 7-10 days | 7-10 days | |
| 1 mg | $2,930 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized HGF Protein, Human, Recombinant at 2 μg/mL (100 μL/well) can bind c-MET Protein, Human, Recombinant (ECD, His & hFc Tag) , the EC50 is 15-70 ng/mL. |
| Description | HGFR/c-Met Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 129.5 kDa and the accession number is A0A024R759. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | His, hFc |
| Accession Number | P08581 |
| Construction | A DNA sequence encoding the extracellular domain (Met1-Thr932) of human c-Met (NP_000236.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. Predicted N terminal: Glu 25 |
| Protein Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, 8% Trehalose, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | RCCP2, MET proto-oncogene, receptor tyrosine kinase, HGFR, DFNB97, c-Met, AUTS9 |
| Research Background | Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 129.5 kDa (predicted); 57.8 kDa and 130 kDa (reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: HGFR/c-Met Protein, Human, Recombinant (His & hFc) chemical structure | HGFR/c-Met Protein, Human, Recombinant (His & hFc) molecular weight
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