HGFR/c-Met Protein, Mouse, Recombinant (His)

Name: HGFR/c-Met Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01896
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Par4, MET proto-oncogene, receptor tyrosine kinase, HGFR, HGF, c-Met, AI838057) Copy Product Info

Synonyms: Par4, MET proto-oncogene, receptor tyrosine kinase, HGFR, HGF, c-Met, AI838057

Catalog No. TMPY-01896 Copy Product Info

Purity: 97.2%

HGFR/c-Met Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102 kDa and the accession number is EDL13881.1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$41	-	In Stock
10 µg	$63	-	In Stock
20 µg	$100	7-10 days	7-10 days
50 µg	$192	7-10 days	7-10 days
100 µg	$320	-	In Stock
200 µg	$567	7-10 days	7-10 days
500 µg	$1,200	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.2%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized HGF Protein, Mouse, Recombinant at 2 μg/mL (100 μL/well) can bind c-MET Protein, Mouse, Recombinant (ECD, His Tag), the EC50 is 80-400 ng/mL.
Description	HGFR/c-Met Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102 kDa and the accession number is EDL13881.1.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	EDL13881.1
Construction	A DNA sequence encoding the mouse MET (EDL13881.1) extracellular domain (Met 1-Asn 929) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Glu 25 & Ser 307
Protein Purity	≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. ,
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	Par4, MET proto-oncogene, receptor tyrosine kinase, HGFR, HGF, c-Met, AI838057
Research Background	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

102 kDa (predicted); 41.8 kDa and 87.2 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.