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Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $42 | In Stock | |
1 g | $50 | In Stock | |
5 g | $79 | In Stock | |
1 mL x 10 mM (in DMSO) | $46 | In Stock |
Description | Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90. |
Targets&IC50 | PI3Kγ:2.4 μM, PI3Kδ:3.0 μM |
In vitro | In xenografts of human prostate cancer LNCaP and PC-3 cells, the combined administration of Quercetin (75 mg/kg) and 2-methoxyestradiol effectively inhibits tumor growth. |
In vivo | Quercetin inhibits TNF-induced LDH release, reduces EC-dependent adhesion of neutrophils to bovine pulmonary artery endothelial cells (BPAEC), and also suppresses DNA synthesis and cell proliferation in these cells. As a PI3K inhibitor (IC50=2.4 - 5.4 μM), quercetin strongly inhibits PI3K and Src kinases, moderately inhibits Akt1/2, and has a slight effect on PKC, p38, and ERK1/2. |
Alias | Sophoretin |
Molecular Weight | 302.24 |
Formula | C15H10O7 |
Cas No. | 117-39-5 |
Smiles | Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O |
Relative Density. | 1.799 g/cm3 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 4 mg/mL (13.23 mM), Sonication is recommended. DMSO: 50 mg/mL (165.43 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||||||||||||
In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.7 mg/mL (18.86 mM), Solution. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.![]() | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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