IL-6 Protein, Mouse, Recombinant

Name: IL-6 Protein, Mouse, Recombinant
Brand: TargetMol
SKU: TMPY-03238
Rating: 4.5 (1 reviews)

(Synonyms: interleukin 6, Il-6) Copy Product Info

Synonyms: interleukin 6, Il-6

Catalog No. TMPY-03238 Copy Product Info

IL-6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is P08505.

Pack Size	Price	USA Stock	Global Stock
5 µg	$70	7-10 days	7-10 days
10 µg	$109	-	In Stock
20 µg	$182	-	In Stock
50 µg	$297	7-10 days	7-10 days
100 µg	$460	-	In Stock
200 µg	$812	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:93.6%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 0.1-0.8 ng/mL.
Description	IL-6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is P08505.
Species	Mouse
Expression System	E. coli
Tag	Tag Free
Accession Number	P08505
Construction	A DNA sequence encoding the mouse IL6 (P08505) (Phe25-Thr211) was expressed and purified. Predicted N terminal: Met
Protein Purity	> 90 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile 50 mM HAC, pH 3, 5% Trehalose, 5% Mannitol, 0.01% Tween-80/Lyophilized from a 0.2 μm filtered solution of 20 mM Tris，5% Sucrose,0.1 mM EDTA,0.1% Tween-80,4% Mannitol, pH 8.0.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	interleukin 6, Il-6
Research Background	Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

21.9 kDa (predicted); 22 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.