IL-17A Protein, Mouse, Recombinant

Name: IL-17A Protein, Mouse, Recombinant
Brand: TargetMol
SKU: TMPY-02900
Price: 85 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: interleukin 17A, IL-17A, IL-17, Il17, Ctla-8, Ctla8) Copy Product Info

Synonyms: interleukin 17A, IL-17A, IL-17, Il17, Ctla-8, Ctla8

Catalog No. TMPY-02900 Copy Product Info

IL-17A Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.5 kDa and the accession number is Q62386.

Pack Size	Price	USA Stock	Global Stock
5 µg	$85	-	In Stock
10 µg	$138	-	In Stock
20 µg	$228	-	In Stock
50 µg	$333	-	In Stock
100 µg	$447	-	In Stock
200 µg	$793	7-10 days	7-10 days
500 µg	$1,680	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:94%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1. Measured by its binding ability in a functional ELISA. Immobilized mouse Il17A at 2 μg/mL (100 μl/well) can bind mouse IL17RA-His , The EC50 of mouse IL17RA-His is 12-45 ng/mL. 2. Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells in the presense of 20 ng/mL TNFα. The ED50 for this effect is 0.15-0.6 ng/mL.
Description	IL-17A Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.5 kDa and the accession number is Q62386.
Species	Mouse
Expression System	E. coli
Tag	Tag Free
Accession Number	Q62386
Construction	A DNA sequence encoding the mature form of mouse IL17a (Q62386) (Thr22-Ala158) was expressed with a N-terminal Met. Predicted N terminal: Met
Protein Purity	> 97 % as determined by SDS-PAGE
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	interleukin 17A, IL-17A, IL-17, Il17, Ctla-8, Ctla8
Research Background	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

15.5 kDa (predicted); 16 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.