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Ibandronate sodium monohydrate

Catalog No. T6539 CAS 138926-19-9

Synonyms: Boniva monohydrate, Bondronat monohydrate, Ibandronate sodium, BM-210955, BM-21.0955, RPR-102289A

Ibandronate sodium monohydrate (BM-210955) is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

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Ibandronate sodium monohydrate Chemical Structure

Ibandronate sodium monohydrate, CAS 138926-19-9

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50 mg	In stock	$ 30.00
100 mg	In stock	$ 40.00
200 mg	In stock	$ 64.00

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Purity: 99.62%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ibandronate sodium monohydrate (BM-210955) is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
In vitro	Ibandronate (1.25–2 μM) significantly reduces endothelial cell growth, while ibandronate (2 μM) also significantly reduces capillary-like tube formation and increases apoptosis of endothelial cells. Ibandronate (< 100 μM) dose-dependently increases VEGF expression in endothelial cells. [1] Ibandronate (< 100 μM) inhibits growth of both prostate cancer cell lines (LNCaP and PC-3) in a dose dependent manner. [2]
In vivo	Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly reduces the risk of new morphometric vertebral fractures by 62% and 50% (p = 0.0006), respectively, in osteoporotic women after 3 years' treatment. Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly and progressively increases BMD of lumbar spine by 6.5% and 5.7%, respectively, in osteoporotic women after 3 years' treatment. [3] Ibandronate (< 125 mg/kg s.c.) results in a dose dependent increase in bone mineral density (BMD), trabecular bone volume and trabecular number, load to failure (Fmax), and yield load in long bones and vertebrae in ovariectomized rats, and increased trabecular separation in ovariectomized rats is fully prevented by all doses. [4]

Synonyms	Boniva monohydrate, Bondronat monohydrate, Ibandronate sodium, BM-210955, BM-21.0955, RPR-102289A
Molecular Weight	360.23
Formula	C9H25NNaO8P2
CAS No.	138926-19-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble

H2O: 10 mM

References and Literature

1. Morgan C, et al. Microvasc Res, 2009, 78(3), 453-458. 2. Epplen R, et al. Acta Oncol, 2011, 50(1), 127-133. 3. Chesnut III CH, et al. J Bone Miner Res, 2004, 19(8), 1241-1249. 4. Bauss F, et al. J Rheumatol, 2002, 29(10), 2200-2208. 5. Wagner D, et al. Transplantation, 2012, 93(3), 331-336.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Orally Active Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Metabolism Disease Compound Library Clinical Compound Library Apoptosis Compound Library

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Keywords

Ibandronate sodium monohydrate 138926-19-9 Apoptosis Others Ibandronate sodium Monohydrate Inhibitor Boniva monohydrate Boniva Bondronat Bondronat monohydrate Ibandronate sodium BM 210955 inhibit BM210955 BM-210955 Boniva Monohydrate BM-21.0955 RPR-102289A Bondronat Monohydrate inhibitor

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