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δ-Tocotrienol

Catalog No. TMA2474 CAS 25612-59-3

Synonyms: Delta-Tocotrienol

δ-Tocotrienol is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce Apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents.

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δ-Tocotrienol, CAS 25612-59-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

δ-Tocotrienol is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents.

In vitro

δ-Tocotrienol induced apoptosis and cell cycle arrest at G0/G1 and M phases in nasopharyngeal carcinoma cells. After CNE1 cells were treated with δ-Tocotrienol, 169 genes were up-regulated and 167 down-regulated. ERK1/2 was shown to play a vital role in cell cycle arrest by gene chips. δ-Tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway. CNE1 apoptosis was related to dysregulated expression of Bax-2 and Bcl-2. Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of δ-Tocotrienol[1].

Synonyms	Delta-Tocotrienol
Molecular Weight	396.61
Formula	C27H40O2
CAS No.	25612-59-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (252.14 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Shen J , et al. δ-Tocotrienol induces apoptosis and inhibits proliferation of nasopharyngeal carcinoma cells. Food Funct. 2021 Jul 21;12(14):6374-6388.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

δ-Tocotrienol 25612-59-3 Angiogenesis Apoptosis Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors PDK BCL VEGFR ERK p53 Akt PI3K inhibit δ Tocotrienol Delta-Tocotrienol Inhibitor δTocotrienol inhibitor

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