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20

Compounds

Cat No. Product Name Synonyms Targets
T40588 Acifluorfen Others
Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX) and induces tumors in rodent livers. It causes significant photooxidative damage to pigments a...
T37885 1-Dodecylimidazole Antifungal
1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that serves as a cytotoxic agent and lysosomotropic detergent. It induces cell death through acid-dependent accumulation in lysosomes, which disrupts the lys...
T6796 CB-5083 CB5083,CB 5083 p97
CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).
T11282 FGTI-2734 Transferase
FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localizat...
T3124 Carbendazim Bavistin,Carbendazole,Mercarzole Antifungal
Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspec...
T0094 Budesonide Entocort,Pulmicort,Rhinocort Glucocorticoid Receptor
Budesonide (Pulmicort), an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Budesonide has extensively inhibitory effects agai...
T9430 Venadaparib NOV140101,IDX-1197 PARP
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the...
T15588 Iobenguane sulfate MIBG sulfate Others
Iobenguane sulfate (MIBG sulfate) is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation). Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmac...
T13044 Mevociclib SY-1365 CDK
Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.
T7318 Elimusertib BAY-1895344 ATM/ATR
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target...
T9240 Sulfopin Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Others
Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo.
T2325 Neratinib HKI-272 EGFR , HER
Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
T22450 Tyrphostin B44, (+) enantiomer EGFR
Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-) enantiomer.
T9303 MRTX1133 Ras
MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.
T31731 Evodenoson DE 112,DE-112,ATL 313,DE112,ATL313,ATL-313 Adenosine Receptor
Evodenoson (ATL313) is a potent and selective adenosine A2a receptor (A2aR) agonist for the treatment of eye diseases, tumors, and immune system disorders, and may be used in studies of open-angle glaucoma and blood tumo...
TNU0123 5-Methoxyuridine Mo5U Apoptosis
5-Methoxyuridine (Mo5U) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.5-Methoxyuridine's anticancer mechanism i...
T68490 CMPF Microtubule Associated
CMPF is a microtubule protein inhibitor that can be used to study tumors.
T26978 CEP-40125 RXDX-107 DNA Alkylation
CEP-40125 (RXDX-107) is a DNA alkylating agent for the study of advanced solid tumors.
T1601 Lomustine CCNU,NSC 79037 Apoptosis , Others , DNA Alkylator/Crosslinker , DNA Alkylation , Autophagy
Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
T3364 Veratramine NSC17821,NSC23880 Sodium Channel
Veratramine (NSC-23880)(NSC-17821; NSC-23880) is a potent signal transduction inhibitor for treating tumors.
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