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Evodenoson

Catalog No. T31731 CAS 844873-47-8

Synonyms: DE 112, DE-112, ATL 313, DE112, ATL313, ATL-313

Evodenoson (ATL313) is a potent and selective adenosine A2a receptor (A2aR) agonist for the treatment of eye diseases, tumors, and immune system disorders, and may be used in studies of open-angle glaucoma and blood tumors.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Evodenoson, CAS 844873-47-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 250.00
5 mg	In stock	$ 630.00
10 mg	In stock	$ 950.00
25 mg	In stock	$ 1,828.00
50 mg	In stock	$ 2,460.00
100 mg	In stock	$ 3,720.00

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Purity: 99.84%

ee: 100%

Purity: 99.74%

ee: 100%

Biological Description

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Description

In vivo

The rats were divided into 3 groups: Group 1 received a continuous intravenous infusion of saline given 10 min prior to ischemia and throughout reperfusion (n=8); Group 2 received a continuous intravenous infusion of 10 ng/kg/min of ATL 313 given 10 min prior to ischemia and throughout reperfusion (n=8); and group 3 received an intravenous bolus of ATL 313 (900 ng/Kg body weight) given 10 min prior to ischemia, and continuous intravenous infusion of 10 ng/kg/min of ATL 313 started at 20 min after ischemia and throughout reperfusion (n=8). After the euthanasia of the rats, the hearts were harvested for the assessment of the risk zone and zone of necrosis of the left ventricle. Conclusion: A(2A)AR agonist ATL 313 significantly reduced infarct size and improved LV contractility at the end of reperfusion assessed by LV dp/dt at a dose of 900 ng/Kg. The mechanisms for the observed cardioprotection effect of ATL 313 remain to be determined.[2]

Synonyms	DE 112, DE-112, ATL 313, DE112, ATL313, ATL-313
Molecular Weight	499.52
Formula	C23H29N7O6
CAS No.	844873-47-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cavalcante IC, et al. Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis. Infect Immun. 2006;74(5):2606-2612. 2. Dai W, et al. ATL 313, A Selective A(2A) Adenosine Receptor Agonist, Reduces Myocardial Infarct Size in a Rat Ischemia/Reperfusion Model. Open Cardiovasc Med J. 2009;3:166-172. 3. Gazoni LM, et al. Additive protection against lung ischemia-reperfusion injury by adenosine A2A receptor activation before procurement and during reperfusion. J Thorac Cardiovasc Surg. 2008;135(1):156-165. 4. Koizumi S, et al. Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. J Gastroenterol. 2009;44(5):419-425.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Evodenoson 844873-47-8 GPCR/G Protein Neuroscience Adenosine Receptor DE 112 DE-112 ATL 313 DE112 ATL313 ATL-313 inhibitor inhibit

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