subtype — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27172	Difamilast		PDE
	Difamilast is an inhibitor of phosphodiesterase IV.		PDE
T22641	CDPPB		GluR
	CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).		GluR
T10539	BIBO3304 TFA		Neuropeptide Y Receptor
	BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor).		Neuropeptide Y Receptor
T15286	Flindokalner	BMS-204352	Potassium Channel
	Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) p...		Potassium Channel
T11394	GFB-8438		TRP/TRPV Channel
	GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).		TRP/TRPV Channel
T4993	Afloqualone	HQ-495	GABA Receptor
	Afloqualone (HQ-495) is a agonist of GABA Receptor . Target: GABA Receptor in vitro: Afloqualone is a quinazolinone family GABAergic drug. It has sedative and muscle-relaxant effects, resulting from its agonist activity ...		GABA Receptor
T15795	Luzindole	N-0774	Melatonin Receptor , MT Receptor
	Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1...		Melatonin Receptor , MT Receptor
T13007	ST1936 oxalate		5-HT Receptor
	ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively).		5-HT Receptor
T9762	Upidosin	SB-216469,SB 216469,Rec 15-2739,Recordati 15/2739	Adrenergic Receptor
	Upidosin (SB-216469) is a potential uroselective α1-adrenoceptor antagonist, α1a subtype Ki=0.34 nM, α1b subtype Ki=3.9 nM, α1d subtype Ki=1.5 nM, α2-adrenoceptor Ki=33.3 nM.		Adrenergic Receptor
T24381	L-822179	L822179,L 822,179,L 822179,L822,179,L-822,179	GABA Receptor
	L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.		GABA Receptor
T17144	TPA 023		GABA Receptor
	TPA 023 is a selective agonist of GABAA α2/α3 subtype (Kis = 0.19 - 0.41 nM).		GABA Receptor
T20968	CyPPA		Potassium Channel , Dopamine Receptor
	CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.		Potassium Channel , Dopamine Receptor
T13241	UB 165 fumarate	UB-165 fumarate,UB165 fumarate	AChR
	UB 165 fumarate is an agonist of the nAChR, a partial agonist of the α4β2 subtype, and a full agonist of the α3β2 subtype, with a Ki value of 0.27 nM for binding to [3H]-nicotine measured in rat brain.		AChR
T26698	AZ044		PI4K
	AZ044 is a potent, selective inhibitor of type III phosphatidylinositol-4-kinase alpha-subtype (PI4KIIIalpha).		PI4K
T8603	ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE		Prostaglandin Receptor
	ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE targets the prostaglandin E2 receptor EP2 subtype (human)		Prostaglandin Receptor
T1028	Moxonidine	BDF5895	Imidazoline Receptor
	Moxonidine (BDF5895) is a selective agonist at the imidazoline receptor subtype 1, acting as an antihypertensive drug.		Imidazoline Receptor
T4138	UCPH-101	UCPH 101	transporter
	UCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with an IC50 of 0.66 μM.		transporter
T3547	Sotagliflozin	LX-4211,LP-802034	SGLT
	Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.		SGLT
T12738L1	Rivanicline 2HCl	Rivanicline 2HCl(15585-43-0 Free base)	AChR
	Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.		AChR
T4540	ML-18		Bombesin Receptor
	ML-18 is a non-peptide bombesin receptor subtype-3 (BRS-3) antagonist with an IC50 of 4.8 μM.		Bombesin Receptor