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CyPPA

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Purity:99.72%

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COA HPLC HNMR

CyPPA

Catalog No. T20968Cas No. 73029-73-9

CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.

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Pack Size	Price	Availability
2 mg	$37	In Stock
5 mg	$59	In Stock
10 mg	$84	In Stock
25 mg	$178	In Stock
50 mg	$296	In Stock
100 mg	$490	In Stock
500 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock

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Product Introduction

Bioactivity

Description	CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
In vitro	CyPPA, a positive modulator of SK2 and SK3, reduces the activity of dopaminergic neurons and inhibits dopamine release with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA counteracts hyperdopaminergic behaviors induced by methylphenidate.
In vivo	In vivo studies revealed that systemic administration of CyPPA attenuated methylphenidate-induced hyperactivity and stereotypic behaviors in mice. CyPPA induces a concentration-dependent increase in the apparent Ca2+ sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM

Chemical Properties

Molecular Weight	285.39
Formula	C16H23N5
Cas No.	73029-73-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 99 mg/mL (346.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5040 mL	17.5199 mL	35.0398 mL	175.1989 mL
5 mM	0.7008 mL	3.5040 mL	7.0080 mL	35.0398 mL
10 mM	0.3504 mL	1.7520 mL	3.5040 mL	17.5199 mL
20 mM	0.1752 mL	0.8760 mL	1.7520 mL	8.7599 mL
50 mM	0.0701 mL	0.3504 mL	0.7008 mL	3.5040 mL
100 mM	0.0350 mL	0.1752 mL	0.3504 mL	1.7520 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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