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CyPPA

Name: CyPPA
Brand: TargetMol
SKU: T20968
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20968Cas No. 73029-73-9

CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.

CyPPA

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Purity: 99.88%

Catalog No. T20968Cas No. 73029-73-9

CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$37	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$84	In Stock	In Stock
25 mg	$178	In Stock	In Stock
50 mg	$296	In Stock	In Stock
100 mg	$490	In Stock	In Stock
500 mg	$1,080	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
Targets&IC50	SK3:14 μM (EC50), SK2:5.6 μM (EC50)
In vitro	CyPPA, a positive modulator of SK2 and SK3, reduces the activity of dopaminergic neurons and inhibits dopamine release with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA counteracts hyperdopaminergic behaviors induced by methylphenidate.
In vivo	In vivo studies revealed that systemic administration of CyPPA attenuated methylphenidate-induced hyperactivity and stereotypic behaviors in mice. CyPPA induces a concentration-dependent increase in the apparent Ca2+ sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM

Chemical Properties

Molecular Weight	285.39
Formula	C₁₆H₂₃N₅
Cas No.	73029-73-9
Smiles	Cc1cc(C)n(n1)-c1nc(C)cc(NC2CCCCC2)n1
Relative Density.	1.23 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 99 mg/mL (346.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5040 mL	17.5199 mL	35.0398 mL	175.1989 mL
5 mM	0.7008 mL	3.5040 mL	7.0080 mL	35.0398 mL
10 mM	0.3504 mL	1.7520 mL	3.5040 mL	17.5199 mL
20 mM	0.1752 mL	0.8760 mL	1.7520 mL	8.7599 mL
50 mM	0.0701 mL	0.3504 mL	0.7008 mL	3.5040 mL
100 mM	0.0350 mL	0.1752 mL	0.3504 mL	1.7520 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc