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UCPH-101

Catalog No. T4138 CAS 1118460-77-7

Synonyms: UCPH 101

UCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with an IC50 of 0.66 μM.

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UCPH-101, CAS 1118460-77-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	UCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with an IC50 of 0.66 μM.
Targets&IC50	EAAT1:0.66 μM.
In vitro	A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048). UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with KD values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102.

Synonyms	UCPH 101
Molecular Weight	422.48
Formula	C27H22N2O3
CAS No.	1118460-77-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10.6 mg/mL(25 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Abrahamsen B, et al. Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J Neurosci. 2013 Jan 16;33(3):1068-87.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UCPH-101 1118460-77-7 Metabolism transporter UCPH 101 inhibit UCPH101 Inhibitor inhibitor

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