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Search Results for " resistant "

20

Compounds

Cat No. Product Name Synonyms Targets
T82715 Cisplatin-resistant cells-IN-1
Cisplatin-resistant cells-IN-1 (Compound 8) exhibits high cytotoxicity against Cisplatin-resistant cells and effectively diminishes metabolic activity at low nanomolar concentrations, with an IC50 ranging from 0.14 to 1....
TN4660 Niranthin Anti-infection , HBV , PAFR , Topoisomerase
Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. N...
T24729 Roseoflavin Antibacterial
Roseoflavin, a chemical analog of FMN and riboflavin that has antimicrobial activity, can directly bind to FMN riboswitch aptamers and downregulate the expression of an FMN riboswitch-lacZ reporter gene in B. subtilis.
T4989 Fosfomycin Tromethamine Antibacterial , Antibiotic
An antibiotic produced by Streptomyces fradiae.
T8722 IKIX1 Antifungal
iKIX1 is an Pdr1-dependent gene activation. It re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection.
TN6512 Tectol Transferase , Parasite
Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 3.44±0.20μM. It exhibited significant activity against human leukemia cell lines HL60 and CEM. Tectol may cause itchy dermatiti...
T11888 LtaS-IN-1 Others , Antibacterial
LtaS-IN-1 is an effective inhibitor of Lipoteichoic acid synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC value...
T8866 GW779439X Apoptosis , Antibacterial , CDK , Aurora Kinase
GW779439X is an inhibitor of CDK.
T8262 Fosfomycin sodium Fosfomycin Disodium Antibacterial , Antibiotic
Fosfomycin sodium is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an e...
T8217 Enzalutamide carboxylic acid Androgen Receptor , Drug Metabolite
Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
T3131 Fosfomycin calcium Phosphomycin calcium salt,Fosmicin Antibacterial , Antibiotic
Fosfomycin calcium (Phosphomycin calcium salt) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis.
TN2027 Oxysanguinarine 8-Oxosanguinarine,Hydroxysanguinarine Parasite
Oxysanguinarine (Hydroxysanguinarine) possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.
T6889 MI-136 Apoptosis , Epigenetic Reader Domain , Androgen Receptor
MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
T64338 AKI603 AKI 603,AKI-603 Aurora Kinase
AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in l...
T19721 Epoxiconazole BAS-480F,BAS 480F,EC 406 850 2,BAS480F,EC-406-850-2 Antifungal
Epoxiconazole (BAS-480F) is a 14-α demethylase inhibitor. It inhibits ergosterol synthesis and fungal cell wall formation.
T24557 NSC756093 NSC-756093,NSC 756093 Others
NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.
T9014 SKI-178 Apoptosis , S1P Receptor
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...
T22263 Bavdegalutamide ARV-110 Androgen Receptor
Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR). Bavdegalutamide can be used in studies about prostate cancer. Bavdegalutamide shows oral activity and selectivity and facilitates the ubiquitinati...
T7700 Lersivirine Lersivirine(UK 453061),UK-453061 HIV Protease , Reverse Transcriptase
Lersivirine (UK-453061)(UK 453061) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy.
T9246 JNJ-63576253 Androgen Receptor
JNJ-63576253 is a Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).
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