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Oxysanguinarine

Catalog No. TN2027 CAS 548-30-1

Synonyms: Hydroxysanguinarine, 8-Oxosanguinarine

Oxysanguinarine possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.

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Oxysanguinarine, CAS 548-30-1

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Purity: 98%

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Description

Oxysanguinarine possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.

In vitro

A total of 2750 phytochemicals from different medicinal plants were selected for this study. These plants grow naturally in the climate of Pakistan and India and have been used for the treatment of various pathologies in humans for a long-time. The ADMET studies, molecular docking and density functional theory (DFT) based analysis was carried out to determine the potential inhibitory properties of these phytochemicals. The ADMET analysis and docking results revealed nine phytochemicals, i.e. Silymarin, Flavobion, Derrisin, Isosilybin, Mundulinol, Silydianin, Isopomiferin, Narlumicine and Oxysanguinarine to have potential inhibitory properties against DENV and can be considered for additional in vitro and in vivo studies to assess their inhibitory effects against DENV replication. They exhibited binding affinity ≥ -8 kcal/mol against DENV4-NS4B. Furthermore, DFT-based analysis revealed high reactivity for these nine phytochemicals in the binding pocket of DENV4-NS4B, based on ELUMO, EHOMO and band energy gap. INTERPRETATION &[1]

Synonyms	Hydroxysanguinarine, 8-Oxosanguinarine
Molecular Weight	347.32
Formula	C20H13NO5
CAS No.	548-30-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: <3.47 mg/mL (10 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Computer-aided analysis of phytochemicals as potential dengue virus inhibitors based on molecular docking, ADMET and DFT studies.J Vector Borne Dis. 2017 Jul-Sep;54(3):255-262.

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Keywords

Oxysanguinarine 548-30-1 Microbiology/Virology Parasite antimalarial resistant inhibit Plasmodium Hydroxysanguinarine falciparum strain 8-Oxosanguinarine Inhibitor inhibitor

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