remodeling — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23312	SB 204741		5-HT Receptor
	SB 204741 is a 5-HT2B receptor antagonist.		5-HT Receptor
T9765	TJ-M2010-5		MyD88
	TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling. TJ-M2010-5 can be used in myocardial ischemia/reperfusion injury studies.		MyD88
T11394	GFB-8438		TRP/TRPV Channel
	GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).		TRP/TRPV Channel
T15418	GS-6201	CVT-6883	Adenosine Receptor
	GS-6201 (CVT-6883) is a selective antagonist of adenosine A2B receptor. GS-6201 shows high affinity and selectivity for the human adenosine A2B receptors with a Ki of 22 nM.		Adenosine Receptor
T5443	JQ-1 (carboxylic acid)	JQ-1 carboxylic acid	Epigenetic Reader Domain
	JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)		Epigenetic Reader Domain
T0543	7-Methylxanthine	Heteroxanthine,Heteroxanthin	Nucleoside Antimetabolite/Analog , Endogenous Metabolite
	7-Methylxanthine (Heteroxanthine), a methyl derivative of xanthine, is one of the purine components in urinary calculi. 7-Methylxanthine appears to prevent FDM in pigmented rabbits by remodeling the posterior sclera.		Nucleoside Antimetabolite/Analog , Endogenous Metabolite
T24115	GSK854	GSK-854,GSK 854	Apoptosis
	GSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury,...		Apoptosis
T13360	XRK3F2		Autophagy
	XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.		Autophagy
T77617	MMP-9-IN-6		MMP
	MMP-9-IN-6 is an MMP-9 inhibitor with an IC50 value of 50 μM and good anti-ulcer efficacy.MMP-9-IN-6 has potential anti-tumor activity and can be used to study tissue remodeling, wound repair and atherosclerosis.		MMP
T9566	PY-60		Annexin A , YAP
	PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional program in the adult animal capable of remodeling the epidermi...		Annexin A , YAP
T12721	Rho-Kinase-IN-1		ROCK
	Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive cell proliferation, remodeling, edema and inflammation dise...		ROCK
T21632	Myoseverin		Others , Microtubule Associated
	Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and str...		Others , Microtubule Associated
T2129	Zaprinast		PDE
	Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist. It has a strong activating effect on rat GPR35 and a certain activating effect on human GPR35. It reduces vascular remodeling through a...		PDE
T20089	ATP	Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate	Endogenous Metabolite
	ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis. ATP can act as an extracellular signaling molecule through interactions with specifi...		Endogenous Metabolite
T3712	Mivebresib	ABBV-075	Apoptosis , Epigenetic Reader Domain
	Mivebresib (ABBV-075), also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the...		Apoptosis , Epigenetic Reader Domain
T3661	Citarinostat	ACY241,HDAC-IN-2	HDAC
	ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ...		HDAC
T28222	5-Hydroxy-1-methylhydantoin	HD-003,HD003,NZ419,NZ-419,HD 003,NZ 419	Bradykinin Receptor
	5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to con...		Bradykinin Receptor
T19472	Nedocromil sodium	Nedocromil disodium salt,FPL 59002KP	Others
	Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.		Others
T28005	MDL-100240
	MDL-100240 is a dual inhibitor of angiotensin-converting enzyme (ACE) and neprilysin with a balanced activity. MDL 100240 shows an impressive effectiveness both in preventing and in regressing hypertension-induced vascul...
T28469	PT-262	PT 262
	PT-262 is a ROCK (Rho-associated coiled-coil forming protein kinase) inhibitor. It induces cytoskeleton remodeling and migration inhibition in lung carcinoma cells.