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Nedocromil sodium

Catalog No. T19472 CAS 69049-74-7

Synonyms: Nedocromil disodium salt, FPL 59002KP

Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.

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Nedocromil sodium, CAS 69049-74-7

Pack Size	Availability	Price/USD
5 mg	35 days	$ 110.00
10 mg	35 days	$ 210.00
25 mg	35 days	$ 483.00
50 mg	35 days	$ 786.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.
In vitro	Nedocromil treatment halted contractile dysfunction in diabetic mice and reduced cardiac mast cell density, which correlated with reduced bioactive enzyme secretions, reduced expression of extracellular matrix remodeling factors and collagen synthesis, and normalized cytokine levels.Nedocromil inhibits the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen (with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively)[1].
In vivo	Treated the diabetic mice with nedocromil for 12 weeks and then examined their hearts for signs of cardiac remodeling and quantified contractile function.?We observed significantly impaired heart function in diabetic mice, as well as increased cardiac mast cell density and elevated mast cell secretions that correlated with gene expression and aberrant cytokine levels associated with cardiac remodeling.

Synonyms	Nedocromil disodium salt, FPL 59002KP
Molecular Weight	394.335
Formula	C19H17NNaO7
CAS No.	69049-74-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.2 mg/mL (12.52 mM), Sonication is recommended.

References and Literature

1. Myocardial remodeling in diabetic cardiomyopathy associated with cardiac mast cell activation. Huang ZG, et al. PLoS One. 2013;8(3):e60827.

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Keywords

Nedocromil sodium 69049-74-7 Others Nedocromil Nedocromil disodium Nedocromil disodium salt FPL 59002KP inhibitor inhibit

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