non-opioid — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9833	Opiranserin hydrochloride		P2X Receptor , GlyT , 5-HT Receptor
	Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50...		P2X Receptor , GlyT , 5-HT Receptor
T6504	Flupirtine maleate	Katadolon maleate	Potassium Channel , NMDAR , iGluR
	Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener.		Potassium Channel , NMDAR , iGluR
T2870	Matrine	Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.		Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
TP1559L	Ziconotide Acetate (107452-89-1 free base)	Prialt,Ziconotide Acetate	Calcium Channel
	Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium chan...		Calcium Channel
T16399	Opiranserin		P2X Receptor , GlyT , 5-HT Receptor
	Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist of glycine transporter type 2 (GlyT2) an...		P2X Receptor , GlyT , 5-HT Receptor
T3720	Tebanicline hydrochloride	ABT-594 hydrochloride,Ebanicline hydrochloride	AChR
	Tebanicline hydrochloride (Ebanicline hydrochloride) , is an effective synthetic nicotinic (non-opioid) analgesic drug.		AChR
T23306	Salvinorin A		Opioid Receptor
	Salvinorin A is a non-nitrogenous κ-opioid selective agonist.		Opioid Receptor
T39349	Vocacapsaicin hydrochloride	CA-008 hydrochloride	TRP/TRPV Channel
	Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.		TRP/TRPV Channel
T0470	Nefopam hydrochloride	Fenazoxine hydrochloride,Nefopam HCl	Wnt/beta-catenin , Sodium Channel
	Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.		Wnt/beta-catenin , Sodium Channel
T39529	AT-121 hydrochloride		Opioid Receptor
	AT-121 hydrochloride is a dual agonist of nociception and mu opioid receptor with Ki values of 3.67 and 16.49 nM, respectively.AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and a...		Opioid Receptor
T8414	SNC 80	Snc-80,SNC80,NIH 10815	Opioid Receptor
	SNC 80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 show...		Opioid Receptor
T37610	AT-121		Opioid Receptor
	AT-121 is a dual μ-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPγS binding to cell membranes expressing either μ-opioid receptors or neuropeptide receptors...		Opioid Receptor
T27253	Elismetrep
	Elismetrep is a non-opioid analgesic.
T23972	DDD028	DDD 028,DDD-028
	DDD-028 is a potential non-opioid and non-cannabinoid analgesic. It was used for treating neuropathic and inflammatory pain.
T34784	TAN67	SB-205607 dihydrobromide,SB 205607 dihydrobromide,SB205607 dihydrobromide,TAN-67,TAN 67
	TAN67 is the first effective selective non-peptide delta1 opioid receptor.
T31631	Enkephalin-leu, ala(2)-ser(6)-	DALES,2-Ala-6-ser-leu-enkephalin
	Enkephalin-leu, ala(2)-ser(6)- is an active compound at the delta (non-complexed) opioid receptor.
T26475	A-286501
	A-286501 is an orally active adenosine kinase inhibitor (IC50=0.47 nM). A-286501 effectively attenuates nociception by a non-opioid, non-non-steroidal anti-inflammatory drug ADO, receptor mediated mechanism.
T25690	Levallorphan tartrate	Lorfan
	Levallorphan tartrate is an opioid antagonist with properties similar to those of NALOXONE. Levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induce...
T70503	Exp 631
	Exp 631 is a centrally-acting non-opioid analgesic; exhibits serotonin and norepinephrine reuptake inhibiting activities.
T23313	SB 205607 dihydrobromide		Others
	non-peptide δ1 opioid receptor agonist		Others