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Opiranserin hydrochloride

Catalog No. T9833 CAS 1440796-75-7

Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.

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Opiranserin hydrochloride, CAS 1440796-75-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.
Targets&IC50	GlyT2:0.86 μM, 5-HT2A Receptor:1.3 μM, rP2X3:0.87 μM

Molecular Weight	430.97
Formula	C21H35ClN2O5
CAS No.	1440796-75-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

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( < 1 mg/ml refers to the product slightly soluble or insoluble )

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Opiranserin hydrochloride 1440796-75-7 VVZ 149 analgesic postoperative VVZ-149 5-hydroxytryptamine Receptor 5-HT Receptor anti-inflammatory Serotonin Receptor Inhibitor pain GlyT Opiranserin non-opioid inhibit P2X Receptor P2XRs VVZ149 Glycine transporters inhibitor

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