malaria — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0690	Quinine		Potassium Channel , Platelet aggregation , Parasite
	Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances...		Potassium Channel , Platelet aggregation , Parasite
T1491	Atovaquone	Atavaquone	Others , P450 , Dehydrogenase , Antibiotic , Parasite
	Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.		Others , P450 , Dehydrogenase , Antibiotic , Parasite
T9741	INE963		Others
	INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h. INE963 is also potent against P. falciparum and P....		Others
T8767	PfDHODH-IN-2		Dehydrogenase , Parasite
	PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor . It is used an antimalarial agent and can be used for the research of m...		Dehydrogenase , Parasite
T12909	SID 26681509		Cysteine Protease , Parasite
	SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).		Cysteine Protease , Parasite
T7938	Quinidine		Parasite
	Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.		Parasite
T6447	Clindamycin	Clinimycin,Sobelin,Chlolincocin	Antibacterial , Antibiotic
	Clindamycin (Sobelin) dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. Clindamycin is a semisynthetic broad-spectrum antibiotic produced by chemical modification of t...		Antibacterial , Antibiotic
T8689	Chloroquine	CQ	SARS-CoV , TLR , HIV Protease , Antibiotic , Parasite , Autophagy
	Chloroquine is a Toll-like receptor inhibitor that inhibits autophagy. Chloroquine has anti-malarial and anti-inflammatory activity and is widely used in the treatment of malaria and rheumatoid arthritis. Chloroquine als...
T4264	Takinib	EDHS-206	Apoptosis , MAPK
	Takinib (EDHS-206) is a specific and effective TAK1 inhibitor(IC50= 9.5 nM).		Apoptosis , MAPK
T0850	Primaquine diphosphate	Primaquine phosphate,Primaquine bisphosphate	Antibiotic , Parasite
	Primaquine diphosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the proper...		Antibiotic , Parasite
T12908	SIBA	5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine	Nucleoside Antimetabolite/Analog , HSV
	SIBA (5'-Deoxy-5'-isobutylthioadenosine) is a synthetic analogue of SAH, acts as an inhibitor of S-adenosylmethionine-mediated transmethylation. SIBA can interfere with a variety of enzymatic activities in vitro, such as...		Nucleoside Antimetabolite/Analog , HSV
T0194	Chloroquine phosphate	Chloroquine diphosphate,Aralen phosphate,Chingamin phosphate	SARS-CoV , TLR , HIV Protease , Antibiotic , Parasite , Autophagy
	Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
T8125	Quinidine sulfate dihydrate	Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate	P450
	Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor		P450
T16269	Nanaomycin A		DNA Methyltransferase , Dehydrogenase , Parasite
	Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).		DNA Methyltransferase , Dehydrogenase , Parasite
T22381	Antimalarial agent 14	4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone	Others
	Antimalarial agent 14 (NSC-102533) is a bioactive chemical.		Others
T79535	Antimalarial agent 30		Parasite
	Antimalarial agent 30 has anti-Plasmodium berghei liver stage parasite activity and antimalarial activity for the study of malarial infections.		Parasite
T10336	Antimalarial agent 1		Parasite
	Antimalarial agent 1 is an effective antimalarial agent.		Parasite
T9984	Antimalarial agent 13	N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine	Parasite
	Antimalarial agent 13 (N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine) is a potent antimalarial agent.		Parasite
T62936	Antimalarial agent 8
	Antimalarial agent 8 (Compound 7e) is a novel, orally active antimalarial agent that is effective against P. falciparum in vitro and effective orally in an in vivo mouse model of malaria (40 mg/kg).
T63655	Antimalarial agent 9
	Antimalarial agent 9 is an effective antimalarial agent, a quinoline-imidazole derivative compound. antimalarial agent 9 showed significant in vitro antimalarial effects against CQ-susceptible strains (IC50-0.14 μM) and ...