Powder: -20°C for 3 years | In solvent: -80°C for 1 year
INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h. INE963 is also potent against P. falciparum and P. vivax clinical isolates from Brazil and Uganda with EC50’s ranging from 0.01 to 7.0 nM
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 57.00 | |
5 mg | In stock | $ 137.00 | |
10 mg | In stock | $ 213.00 | |
25 mg | In stock | $ 435.00 | |
50 mg | In stock | $ 643.00 | |
100 mg | In stock | $ 915.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 163.00 |
Description | INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h. INE963 is also potent against P. falciparum and P. vivax clinical isolates from Brazil and Uganda with EC50’s ranging from 0.01 to 7.0 nM |
Targets&IC50 | Pf3D7:6 nM(EC50) |
In vitro | INE963 is active against >15 drug-resistant Pf cell lines with EC50’s = 0.5–15 nM. The in vitro log parasite reduction ratio for INE963 is >8.0 at 10 × Pf 3D7 EC50 without a lag phase and a parasite clearance time (PCT99.9) of <24 h. The in vitro selectivity of INE963for Plasmodium vs human cells was exemplified by approximately 1000+ fold shifts against multiple human kinase biochemical assays[1]. |
In vivo | Following four oral doses at 30 mg/kg of INE963, the frontrunner compounds tested showed significant parasitemia reduction (>99.9%) at day 5 compared to untreated control mice. In addition, the animals did not show any signs of recrudescence of parasite at day 60 post-treatment, indicating complete cure at these doses[1]. |
Molecular Weight | 402.51 |
Formula | C19H26N6O2S |
CAS No. | 2640567-43-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (124.22 mM)
You can also refer to dose conversion for different animals. More
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INE963 2640567-43-5 Others uncomplicated malaria inhibit INE 963 Parasite antimalarial INE-963 Inhibitor inhibitor