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Clindamycin

Catalog No. T6447 CAS 18323-44-9

Synonyms: Clinimycin, Sobelin, Chlolincocin

Clindamycin (Sobelin) dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. Clindamycin is a semisynthetic broad-spectrum antibiotic produced by chemical modification of the parent compound lincomycin.

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Clindamycin, CAS 18323-44-9

Pack Size	Availability	Price/USD
25 mg	In stock	$ 42.00
50 mg	In stock	$ 59.00
100 mg	In stock	$ 81.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.87%

Purity: 99.52%

Purity: 98.04%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Clindamycin (Sobelin) dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. Clindamycin is a semisynthetic broad-spectrum antibiotic produced by chemical modification of the parent compound lincomycin.
In vitro	Clindamycin is a semisynthetic analogue of lincomycin. Clindamycin primarily inhibits the initiation of peptide chain synthesis by deregulating enzyme-catalyzed initiation of peptide bounds. Clindamycin appears to have a modest effect on protein synthesis by certain mammalian cells. [1] Clindamycin is active against most gram-positive aerobic bacteria. Clindamycin is about eight times more active than lincomycin against Staphylococcus aureus and Streptococcus pneumonia. Clindamycin is four times more active than erythromycin against S. aureus and is active even against strains that are resistant to erythromycin, penicillin, and methicillin. Clindamycin is active against gram-positive anaerobes. Clindamycin highly activates against Bacteroides specie. [2] Clindamyci also alters the bacterial surface in such a way that phagocytosis and intracellular killing of the bacteria is greatly facilitated. Clindamycin potentiates opsonization and phagocytosis. [4]
In vivo	Clindamycin (50 mg/kg daily administrated by intramuscular) increases the survival rate of monkeys infected with penicillin-resistant S. aureu to 87.5% (7/8). [5] Clindamycin (40 mg/kg administrated three times daily) protects 87.5% (7/8) of rabbits from anaerobic pulmonary infections induced by transtracheal inoculation of a mixture of B. fragillis, Streptococcus morbillorm, Fusobacterium nucleatum and Eubacterium lentum. [6] Clindamycin (400 mg/kg treated by mixed in the diet) increases survival rate of mice infected with the Toxoplasma gondii to 100%, while all animals die in untreated group. [7]

Synonyms	Clinimycin, Sobelin, Chlolincocin
Molecular Weight	424.98
Formula	C18H33ClN2O5S
CAS No.	18323-44-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 79 mg/mL (185.9 mM)

Ethanol: 79 mg/mL (185.9 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Keusch GT, et al. J Infect Dis, 1976, 133(5), 578-587. 2. Dhawan VK, et al. Rev Infect Dis, 1982, 4(6), 1133-1153. 3. Carlisle HN, et al. Appl Microbiol, 1971, 21(3), 440-446. 4. Gemmell CG, et al. J Clin Invest, 1981, 67(5), 1249-1256. 5. McGehee RF Jr, et al. Am J Med Sci, 1968, 256(5), 279-292. 6. Hodille E, et al. Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains. Ann Clin Microbiol Antimicrob. 2018 Oct 20;17(1):38.

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Drug Repurposing Compound Library Natural Product Library for HTS Antibiotics Library Orally Active Compound Library RO5 Drug-like Natural Product Library Approved Drug Library Anti-Bacterial Compound Library Clinical Compound Library ReFRAME Related Library

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Keywords

Clindamycin 18323-44-9 Microbiology/Virology Antibiotic Antibacterial broad-spectrum Clinimycin Sobelin Parasite Inhibitor inhibit Chlolincocin bacteriostatic Bacterial lincosamide malaria inhibitor

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