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Quinidine

Catalog No. T7938   CAS 56-54-2

Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.

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Quinidine Chemical Structure
Quinidine, CAS 56-54-2
Pack Size Availability Price/USD Quantity
100 mg In stock $ 48.00
1 mL * 10 mM (in DMSO) In stock $ 54.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.
In vitro Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes[1].
Source
Molecular Weight 324.42
Formula C20H24N2O2
CAS No. 56-54-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (154.12 mM)

TargetMolReferences and Literature

1. Salata J J , Wasserstrom J A . Effects of quinidine on action potentials and ionic currents in isolated canine ventricular myocytes[J]. Circulation Research, 1988, 62(2):324-337. 2. Guentert T W , Upton R A , Holford N H , et al. Gastrointestinal absorption of quinidine from some solutions and commercial tablets[J]. Journal of Pharmacokinetics & Biopharmaceutics, 1980, 8(3):243-255. 3. Benton R E , Sale M , Flockhart D A , et al. Greater quinidine-induced QTc interval prolongation in women[J]. Clinical pharmacology and therapeutics, 2000, 67(4):413.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Parasitic Compound Library Antiparasitic Natural Product Library Drug Repurposing Compound Library CNS-Penetrant Compound Library Human Metabolite Library Gut Microbial Metabolite Library Selected Plant-Sourced Compound Library Approved Drug Library Inhibitor Library Bioactive Compounds Library Max

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Keywords

Quinidine 56-54-2 Microbiology/Virology Parasite MES-SA Inhibitor CYPs Potassium Channel Cytochrome P450 MESSA/DX5 Apoptosis oral activity KcsA malaria inhibit inhibitor

 

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