mtorc2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T35343	MTI-31	MTI-31,LXI-15029	mTOR
	MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding a...		mTOR
T11728	JR-AB2-011		mTOR
	JR-AB2-011 is a selective mTORC2 inhibitor with an IC 50 value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association ( K i : 0.19 μM) and is cytotoxic in glioblastoma [1].		mTOR
T2475	KU-0063794		mTOR
	KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.		mTOR
T6319	OSI-027	ASP4786,OSI027	DNA-PK , PI3K , mTOR , Autophagy
	OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. Phase 1.		DNA-PK , PI3K , mTOR , Autophagy
T12123	MTOR inhibitor-3		mTOR
	mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.		mTOR
T9156	CDC25B-IN-2		Phosphatase , mTOR
	BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.		Phosphatase , mTOR
T8649	TMBIM6 antagonist-1	BAX-inhibitor-1,BIA	mTOR
	TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor		mTOR
T36200	AZD 3147		mTOR
	AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.		mTOR
T14552	Dactolisib Tosylate	BEZ235 Tosylate,NVP-BEZ 235 Tosylate	PI3K , mTOR
	Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR. dactolisib Tosylate exhibits IC50 values of 4, 75, 7, and 5 nM for PI3Kα, β, γ, and δ, respectively. dactolisib Tosylate inhibi...		PI3K , mTOR
T6732	WYE-687		p38 MAPK , PI3K , Src , mTOR
	WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fol...		p38 MAPK , PI3K , Src , mTOR
T6731	WYE-354		Apoptosis , PI3K , mTOR , Autophagy
	WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selectivity for mTOR is higher than PI3Kα (>100-fold) and PI3Kγ ...		Apoptosis , PI3K , mTOR , Autophagy
T6730	WAY-600	WAY600	VEGFR , PI3K , Src , mTOR
	WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold...		VEGFR , PI3K , Src , mTOR
T3514	CZ415		mTOR
	CZ415 is a potent and highly selective mTOR inhibitor.		mTOR
T2414	Torkinib	PP 242	Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
	Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).		Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
T3541	CC-115	CC 115	DNA-PK , PI3K , mTOR
	CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).		DNA-PK , PI3K , mTOR
T1961	Vistusertib	AZD2014	Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy
	Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.		Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy
T6103	VS-5584	SB2343,VS 5584,VS5584	PI3K , mTOR
	VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.		PI3K , mTOR
T6030	XL388		P450 , PI3K , mTOR
	XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.		P450 , PI3K , mTOR
T2706	Palomid 529	P529,SG 00529	Apoptosis , mTOR
	Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.		Apoptosis , mTOR
T1859	AZD-8055		Apoptosis , mTOR , Autophagy
	AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.		Apoptosis , mTOR , Autophagy