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PI3K/Akt/mTOR signaling MTOR JR-AB2-011

JR-AB2-011

Catalog No. T11728   CAS 329182-61-8

JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM). JR-AB2-011 has anti-glioblastoma multiforme (GBM) properties. JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM.

JR-AB2-011, CAS 329182-61-8
Pack Size Availability Price/USD Quantity
5 mg In stock 232.00
10 mg In stock 390.00
25 mg In stock 829.00
50 mg In stock 1410.00
100 mg In stock 2289.00
200 mg In stock Inquiry
500 mg In stock Inquiry
1 mL * 10 mM (in DMSO) In stock 254.00
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Purity 98.87%
Biological Description
Chemical Properties
Storage & Solubility Information
Description JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM). JR-AB2-011 has anti-glioblastoma multiforme (GBM) properties. JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM.
Targets&IC50 mTORC2
In vivo JR-AB2-011 at 20 mg/kg/d; 80% inhibition at end of dosing period; tumor growth delay 12.0 days) as compared to mice receiving vehicle alone.Mice receiving JR-AB2-011 (4 mg/kg; daily i.p. for 10 days; 20 mg/kg; daily i.p. for 10 days) at either dosing regimen display marked inhibition of tumor growth rate (JR-AB2-011 at 4 mg/kg/d; 74% inhibition at end of dosing period; tumor growth delay 10.0 days.
Molecular Weight 398.28
Formula C17H14Cl2FN3OS
CAS No. 329182-61-8

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 61.5 mg/mL(154.41 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Benavides-Serrato A, et al. Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxicin glioblastoma. PLoS One. 2019 Feb 6;14(2):e0212160.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-Cancer Compound Library Anti-Diabetic Compound Library Stem Cell Differentiation Compound Library Autophagy Compound Library Oxidation-Reduction Compound Library PI3K-AKT-mTOR Compound Library Kinase Inhibitor Library Anti-Cancer Metabolism Compound Library Anti-Aging Compound Library Anti-Cancer Active Compound Library HIF-1 Signaling Pathway Compound Library Anti-Lung Cancer Compound Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Glutamine Metabolism Compound Library

Related Products

Related compounds with same targets
JR-AB2-011 PQR-530 TMBIM6 antagonist-1 DMH-25 LY-2584702 free base N6-Cyclopentyladenosine 9,9'-Di-O-(E)-feruloylsecoisolariciresinol FT-1518

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