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JR-AB2-011

Catalog No. T11728 CAS 2411853-34-2

JR-AB2-011 is a selective mTORC2 inhibitor with an IC 50 value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association ( K i : 0.19 μM) and is cytotoxic in glioblastoma [1].

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JR-AB2-011, CAS 2411853-34-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 117.00
5 mg	In stock	$ 283.00
10 mg	In stock	$ 419.00
25 mg	In stock	$ 697.00
50 mg	In stock	$ 995.00
100 mg	In stock	$ 1,330.00
1 mL * 10 mM (in DMSO)	In stock	$ 293.00

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Purity: 98.87%

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Description	JR-AB2-011 is a selective mTORC2 inhibitor with an IC 50 value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association ( K i : 0.19 μM) and is cytotoxic in glioblastoma [1].
Targets&IC50	mTORC2:0.36 μM
In vitro	JR-AB2-011 (1 μM; 24 hours) shows good anti-GBM properties, blocks mTORC2 signaling and Rictor association with mTOR [1]. JR-AB2-011 (0.5-2 μM; 48 hours) displays the least toxicity to normal neurons with no significant cytotoxic effects for concentrations up to 10 mM compared to CID613034 [1]. Apoptosis Analysis [1] Cell Line: U87 GBM cells; LN229 GBM cells Concentration: 1 μM Incubation Time: 24 hours Result: Had good anti-GBM properties and blocked mTORC2 signaling and Rictor association with mTOR. Cell Cytotoxicity Assay [1] Cell Line: Normal mature human neurons Concentration: 0.5, 1, 2 μM Incubation Time: 48 hours Result: Displayed the least toxicity to normal neurons with no significant cytotoxic effects for concentrations up to 10 mM.
In vivo	Mice receiving JR-AB2-011 (4 mg/kg; daily i.p. for 10 days; 20 mg/kg; daily i.p. for 10 days) at either dosing regimen show significant inhibition of tumor growth rate (JR-AB2-011 at 4 mg/kg/d; 74% inhibition at end of dosing period; tumor growth delay 10.0 days; JR-AB2-011 at 20 mg/kg/d; 80% inhibition at end of dosing period; tumor growth delay 12.0 days) as compared to mice receiving vehicle alone [1]. Animal Model: LN229 cells in female C.B.-17-scid (Taconic) mice [1] Dosage: 4 mg/kg; 20 mg/kg Administration: Daily i.p.; 10 days Result: Either dosing regimen displayed marked inhibition of tumor growth rate as compared to mice receiving vehicle alone.

Molecular Weight	398.28
Formula	C17H14Cl2FN3OS
CAS No.	2411853-34-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 61.5 mg/mL(154.41 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Benavides-Serrato A, et al. Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxicin glioblastoma. PLoS One. 2019 Feb 6;14(2):e0212160.

Citations

1. Xu W, Qadir M M F, Nasteska D, et al.Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells.Cell Reports.2023, 42(5).

Related compound libraries

This product is contained In the following compound libraries：

Neural Regeneration Compound Library Bioactive Compound Library Anti-Diabetic Compound Library Anti-Liver Cancer Compound Library Anti-Ovarian Cancer Compound Library PI3K-AKT-mTOR Compound Library Anti-Aging Compound Library Stem Cell Differentiation Compound Library HIF-1 Signaling Pathway Compound Library Antidepressant Compound Library

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Keywords

JR-AB2-011 2411853-34-2 PI3K/Akt/mTOR signaling mTOR JRAB2011 JR-AB-2-011 JR AB2 011 inhibitor inhibit

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