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CC-115

Catalog No. T3541 CAS 1228013-15-7

Synonyms: CC 115

CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CC-115, CAS 1228013-15-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 126.00
25 mg	In stock	$ 238.00
50 mg	In stock	$ 425.00
100 mg	In stock	$ 628.00
1 mL * 10 mM (in DMSO)	In stock	$ 88.00

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Purity: 99.22%

Purity: 86.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
Targets&IC50	mTOR:21nM, DNA-PK:13 nM
In vitro	The IC50 values for CC-115 are >10 μM against a panel of CYP enzymes and >33 μM for the hERG ion channel. When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target was inhibited >50% (PDE3, IC50 = 0.63 μM).
In vivo	CC-115 shows good PK profiles across multiple species with 53%, 76%, and 100% oral bioavailability in mouse, rat, and dog, respectively. CC-115, with favorable physicochemical and pharmacokinetic properties, demonstrates mTOR pathway inhibition and tumor growth inhibition, as well as a good safety profile, suitable for Clinicalal development.
Cell Research	Freshly isolated CLL cells are treated with different concentrations of CC-115 for 30 minutes. Subsequently, the cells are exposed to 5-Gy γ-radiation or treated with 10 µg/mL bleomycin (EMD Millipore, Billerica, MA) and incubated for 30 minutes, and cell lysates are made. (Only for Reference)

Synonyms	CC 115
Molecular Weight	336.35
Formula	C16H16N8O
CAS No.	1228013-15-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 62 mg/mL (184.3 mM)

References and Literature

1. Thijssen R, et al. Blood. 2016, 128(4):574-83. 2. Mortensen DS, et al. J Med Chem. 2015, 58(14):5599-608.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Drug Repurposing Compound Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Drug Library DNA Damage & Repair Compound Library Glycolysis Compound Library Angiogenesis related Compound Library

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Related compounds with same targets

Voxtalisib DNA-PK-IN-10 PI-3065 NU6027 Onatasertib PI3K-IN-1 LTURM34 YU238259

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CC-115 1228013-15-7 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling PI3K DNA-PK mTOR DNA-dependent protein kinase CC115 inhibit CC 115 Inhibitor Mammalian target of Rapamycin inhibitor

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