Powder: -20°C for 3 years | In solvent: -80°C for 1 year
mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 67.00 | |
2 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 163.00 | |
10 mg | In stock | $ 228.00 | |
25 mg | In stock | $ 395.00 | |
50 mg | In stock | $ 589.00 | |
100 mg | In stock | $ 843.00 | |
500 mg | In stock | $ 1,730.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 169.00 |
Description | mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments. |
Targets&IC50 | mTOR:1.5 nM (ki) |
In vitro | mTOR inhibitor-3 is an mTOR inhibitsor(Ki of 1.5 nM), 500-fold selectivity over closely related PI3 kinases.?mTOR inhibitor-3 inhibits NCI-PC3 and MCF7neo/Her2 cells proliferation with IC50s of 150 nM and 57 nM, respectively[2]. |
In vivo | mTOR inhibitor-3 achieves tumor stasis at the highest 200 mg/kg/day dose examined, which appears to also be approaching the limit of tolerability for this molecule. Plasma levels of mTOR inhibitor-3 6 h following oral administration in PC3 tumor-bearing mice along with the fold decreases of phosphorylated mTORC1 and -2 substrates relative to time-matched vehicle controls.?mTOR inhibitor-3 has moderate terminal elimination half-life (t1/2=1.7 h for mouse(1 mg/kg, iv))?[2]. |
Molecular Weight | 474.56 |
Formula | C25H30N8O2 |
CAS No. | 1207358-59-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (94.82 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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mTOR inhibitor-3 1207358-59-5 PI3K/Akt/mTOR signaling mTOR Inhibitor inhibit mTOR inhibitor 3 mTOR inhibitor3 Mammalian target of Rapamycin inhibitor