impairment — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3S0195	Nootkatone		AMPK
	1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activa...		AMPK
TN2100	Pratensein		Others , NF-κB
	Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.		Others , NF-κB
T19438	Myristyl nicotinate	Tetradecyl nicotinate	GPR
	Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug being developed for delivery of nicotinic acid (NIC) into the skin for prevention of actinic keratosis and its progression to skin cancer.		GPR
T22012	7BIO		FLT , DYRK , Aurora Kinase
	7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.		FLT , DYRK , Aurora Kinase
T2230	Paeoniflorin	Peoniflorin	HSP , COX
	Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.		HSP , COX
T19659	Annaosanchun	YC6,YC-6,YC 6	Others , AMPK
	Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).		Others , AMPK
T7530	PD146176	NSC168807	Ferroptosis , Lipoxygenase , Autophagy
	PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology...		Ferroptosis , Lipoxygenase , Autophagy
T28368	PF-04859989 HCl	PF 04859989,PF04859989,PF-04859989HCl,PF-04859989	Others
	PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s...		Others
T7060	Amantadine	1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine	Others
	Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.		Others
T1406	Amantadine hydrochloride	1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor , Influenza Virus
	Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.		Dopamine Receptor , Influenza Virus
T34435	RU 47213	RU-47213,Itameline,RU47213	Others
	RU 47213 can be used to inhibit scopolamine-induced working memory impairment in rats.		Others
T16881	SIB-1553A hydrochloride		AChR
	SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.SIB-1553A hydrochloride enhances cognition and may be useful in the study of Alzhei...		AChR
T37184	CX08005	2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid	Phosphatase
	CX08005 is a protein tyrosine phosphatase 1B inhibitor. CX08005 reduces hepatic lipid accumulation and microcirculatory impairment associated with non-alcoholic fatty liver disease.		Phosphatase
T7193	Encenicline	EVP-6124	AChR
	Encenicline (EVP-6124) is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheimer's disease.		AChR
T13151L	THK5351		Others
	THK5351 is a tracer involved in PET imaging for electron emission tomography imaging of Alzheimer's disease and cognitive impairment.		Others
T31079	CP-810123	CP 810123,UNII-E6G4550EC4,CP810123	AChR
	CP-810123 is a new alpha 7 nAChR agonist for the treatment of cognitive impairment associated with psychiatric or neurological disorders such as schizophrenia and Alzheimer's disease.		AChR
T77678	TZ3O		AChR
	TZ3O is an anticholinergic compound with neuroprotective activity.TZ3O ameliorates memory impairment and cognitive decay in Scopolamine-induced Alzheimer's type model in rats, and can be used in the study of Alzheimer's ...		AChR
T1884	CX516	Ampakine CX516,BDP 12,Ampalex	GluR , iGluR
	CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).		GluR , iGluR
TN2230	Soyasaponin Ba		Others
	Soyasaponin Ba may represent viable candidates for effective vaccine adjuvants due to their higher and lower or non-haemolytic effects.Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without ...		Others
T19812	Propentofylline	HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285	PDE
	Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine signaling, which may be useful in the study of Alzheimer's d...		PDE