Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.SIB-1553A hydrochloride enhances cognition and may be useful in the study of Alzheimer's disease and cognitive impairment.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 93.00 | |
5 mg | In stock | $ 235.00 | |
10 mg | In stock | $ 378.00 | |
25 mg | In stock | $ 626.00 | |
50 mg | In stock | $ 883.00 | |
100 mg | In stock | $ 1,190.00 |
Description | SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.SIB-1553A hydrochloride enhances cognition and may be useful in the study of Alzheimer's disease and cognitive impairment. |
In vitro | In calcium flux assays, compared to nicotine, SIB-1553A hydrochloride (0.1-5 μM) exhibits higher selectivity in both potency and efficacy towards β4 subunits containing recombinant hnAChRs (α2β4, α3beta4, and α4β4) over β2 subunits containing nAChRs (α4β2 and α3beta2)[1]. |
In vivo | In Male Sprague-Dawley rats (200-250 g), SIB-1553A hydrochloride (1, 2, 4, 10, 20, and 40 mg/kg; s.c) induced hippocampal ACh release[2]. |
Molecular Weight | 273.82 |
Formula | C13H20ClNOS |
CAS No. | 191611-89-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: H2O: 20 mg/mL (73.04 mM)
You can also refer to dose conversion for different animals. More
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SIB-1553A hydrochloride 191611-89-9 Neuroscience AChR SIB-1553A SIB1553A SIB 1553A inhibitor inhibit