cortex — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8270	Deserpidine	Harmonyl	RAAS
	Deserpidine (Harmonyl) is only found in individuals that have used or taken this drug. It is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive propertie...		RAAS
T2150	Guanfacine hydrochloride	Tenex,Intuniv,Guanfacine	Adrenergic Receptor
	Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.		Adrenergic Receptor
T1566	Aripiprazole	OPC-14597	5-HT Receptor
	Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a...		5-HT Receptor
T8143	Bevantolol hydrochloride	NC-1400 hydrochloride	Calcium Channel , Adrenergic Receptor
	Bevantolol hydrochloride (NC-1400 hydrochloride) is a β1-adrenoceptor antagonist that treatment angina pectoris and hypertension.		Calcium Channel , Adrenergic Receptor
T4297	Flibanserin	BIMT-17BS,Girosa,BIMT-17	Dopamine Receptor , 5-HT Receptor
	Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n...		Dopamine Receptor , 5-HT Receptor
T0508	γ-Aminobutyric acid	Gamma-aminobutyric acid,4-Aminobutyric acid,GABA,4-Aminobutanoic acid,Piperidic acid	GABA Receptor , Endogenous Metabolite
	γ-Aminobutyric acid (4-Aminobutyric acid) is the most common inhibitory neurotransmitter in the central nervous system.		GABA Receptor , Endogenous Metabolite
T13007	ST1936 oxalate		5-HT Receptor
	ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively).		5-HT Receptor
T7026	KukoaMine B		Antioxidant
	Kukoamine B, as a constituent of Lycii Cortex, exhibits anti-acute inflammatory, anti-oxidant, and anti-diabetic characteristics.		Antioxidant
TN6900	Reptoside		Others
	Reptoside, which can be extracted from the roots and above-ground parts of Cortex Eucommiae and Ajuga chamaepitys (L.) Schreb, is one of the active cyclic enol ether terpene glycosides of Cortex Eucommiae for the treatme...		Others
T27252	ELB-139	ELB139
	ELB-139 is a GABA A receptor agonist. ELB139 increases 5-HT in the striatum and prefrontal cortex of rats.
T14083	Abaperidone		Dopamine Receptor , 5-HT Receptor
	Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound th...		Dopamine Receptor , 5-HT Receptor
TP1851L	Scyliorhinin II acetate		Neurokinin receptor
	Scyliorhinin II acetate is a selective agonist of the neurokinin-3 (NK3) receptor (Ki = 2.5 nM) in rat cerebral cortex.		Neurokinin receptor
T0856	Dehydroisoandrosterone 3-acetate	Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,androstenolone acetate	Androgen Receptor
	Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.		Androgen Receptor
T1473	Trilostane	Win 24540	Dehydrogenase
	Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex.		Dehydrogenase
T5147	Polygalaxanthone XI		Others
	Polygalaxanthone XI, an oxygenated xanthone glycoside isolated from the cortex of Polygala tenuifolia, is utilized in research for its expectorant properties and potential to promote mental tranquility.		Others
T3887	Rosarin		Others
	Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice .		Others
T66580	Azilsartan Methyl Ester		RAAS
	Azilsartan Methyl Ester is an angiotensin II receptor antagonist. Azilsartan Methyl Ester inhibits specific binding of [125I]AII (0.2 nM) to bovine adrenal cortex with IC50 value is 0.44uM.		RAAS
T1199	Mitotane	Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD	Apoptosis , AChR
	Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors a...		Apoptosis , AChR
T4814	(R)-5-Oxopyrrolidine-2-carboxylic acid	D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid	Others , Endogenous Metabolite
	(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of glutamic acid, physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and di...		Others , Endogenous Metabolite
T5850	Benzamil	Benzamil (hydrochloride)	Na+/Ca2+ Exchanger , Sodium Channel
	Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles.		Na+/Ca2+ Exchanger , Sodium Channel