contractions — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22285	Carboprost	15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α	Prostaglandin Receptor
	Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic. Carboprost is commonly used to restore uterine tone.		Prostaglandin Receptor
T3023	Catharanthine sulfate		AChR
	Catharanthine inhibits nicotinic receptor-mediated diaphragm contractions.		AChR
TN1624	Ethyl cinnamate		Calcium Channel , ROS , NO Synthase
	Ethyl cinnamate has antifungal, and vasorelaxant effects. Ethyl cinnamate can lead to the damage of cell membrane system and metabolic disorder through inducing lipid peroxidation via initiating ROS overproduction. Ethyl...		Calcium Channel , ROS , NO Synthase
T2782	Catharanthine	(+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine	Calcium Channel , AChR
	Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).		Calcium Channel , AChR
T1433	Ritodrine hydrochloride	DU21220,Ritodrine HCl,NSC 291565	Adrenergic Receptor
	Ritodrine hydrochloride (NSC 291565) binds to and activates beta-2 adrenergic receptors of myometrial cells in the uterus, which decreases the intensity and frequency of uterine contractions. Ritodrine hydrochloride (NS...		Adrenergic Receptor
TN2540	1-Hydroxybaccatin I		Others
	1-Hydroxybaccatin I possesses significant antinociceptive activity against p- benzoquinone-induced abdominal contractions.		Others
T28855	SSR126768A	SSR-126768A,SSR 126768A	Oxytocin Receptor
	SSR126768A is a novel and selective, orally active and potent oxytocin (OT) receptor antagonist with inhibitory effects on uterine contractions for the prevention of preterm labor.		Oxytocin Receptor
T14326	AS-35		Others
	AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum. With IC50 values of 8 nM, 4 nM and 3 nM, respectively. It has antiallergi...		Others
T12255	NS19504		Potassium Channel
	NS19504 is an activator of Ca2+-activated K+ channel with EC50 of 11.0 µM. NS19504 shows relaxing effect on bladder smooth muscle spontaneous phasic contractions[1].		Potassium Channel
T14865	Carboprost tromethamine		Prostaglandin Receptor
	Carboprost tromethamine, a synthetic 15-methyl analogue of prostaglandin F2α, effectively promotes uterine contractions and significantly reduces bleeding during and post-delivery.		Prostaglandin Receptor
T5148	Atosiban acetate	RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164	Oxytocin Receptor , Vasopressin Receptor
	Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits...		Oxytocin Receptor , Vasopressin Receptor
T0771	Casanthranol		Others
	Casanthranol is a concentrated mixture of anthranol glycosides derived from the dried bark of Rhamnus p., commonly known as cascara sagrada. This compound serves as a stimulant laxative that is primarily administered to ...		Others
T1475	Fesoterodine fumarate	Toviaz,SPM 907	AChR
	Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo...		AChR
T1435	Praziquantel	Pyquiton,Droncit,Biltricide	Calcium Channel , Antibiotic , Parasite
	Praziquantel (Droncit) increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculatur...		Calcium Channel , Antibiotic , Parasite
TP2106L	Urantide acetate(669089-53-6 free base)		Neurotensin Receptor
	Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced ...		Neurotensin Receptor
T72038	YM-58790	YM-58790 free base	AChR
	YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder c...		AChR
T68123	Oxodipine		Calcium Channel
	Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventri...		Calcium Channel
T2520	Desloratadine	Sch34117,NSC 675447	Endogenous Metabolite , Histamine Receptor
	Desloratadine (Sch34117) is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smoot...		Endogenous Metabolite , Histamine Receptor
TP1198	Sincalide ammonium	SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium	cholecystokinin
	Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secr...		cholecystokinin
T33449	ML 1035	ML103,ML-1035
	ML 1035 is a benzamide that elicits contractions from guinea-pig non-stimulated ileum.