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Fesoterodine fumarate

Catalog No. T1475 CAS 286930-03-8

Synonyms: Toviaz, SPM 907

Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo into its active metabolite 5-hydroxymethyl tolterodine, which binds and inhibits muscarinic receptors on the bladder detrusor muscle, thereby preventing bladder contractions or spasms caused by acetylcholine.

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Fesoterodine fumarate Chemical Structure

Fesoterodine fumarate, CAS 286930-03-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 77.00
25 mg	In stock	$ 113.00
50 mg	In stock	$ 155.00
100 mg	In stock	$ 239.00
500 mg	In stock	$ 463.00
1 mL * 10 mM (in DMSO)	In stock	$ 55.00

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Purity: 98%

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Description

In vitro

Fesoterodine is rapidly and extensively converted to 5-HMT, such that the pharmacologic activity appears to be primarily attributable to 5-HMT. [1] Fesoterodine is a competitive antagonist of cholinergic agonist-stimulated responses in human M1-M5 cell lines and has a similar potency and selectivity profile to the radioligand-binding studies. Fesoterodine causes a rightward shift of the concentration-response curve for carbachol with no depression of the maximum in rat bladder strips, and concentration-dependently reduces contractions induced by electrical field stimulation (EFS). [2] Fesoterodine is hydrolyzed by nonspecific esterases to 5-hydroxmethyl tolterodine (5-HMT), which is the active metabolite and is responsible for all its antimuscarinic activity. [3]

Synonyms	Toviaz, SPM 907
Molecular Weight	527.65
Formula	C26H37NO3·C4H4O4
CAS No.	286930-03-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 93 mg/mL (176.3 mM)

H2O: 92 mg/mL (174.4 mM)

Ethanol: 93 mg/mL (176.3 mM)

References and Literature

1. Malhotra B, et al. Curr Med Chem, 2009, 16(33), 4481-4489. 2. Ney P, et al. BJU Int, 2008, 101(8), 1036-1042. 3. Vella M, et al. Expert Opin Drug Saf, 2011, 10(5), 805-808.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Inhibitor Library EMA Approved Drug Library Bioactive Compounds Library Max Orally Active Compound Library Bioactive Compound Library Clinical Compound Library Anti-Alzheimer's Disease Compound Library

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Keywords

Fesoterodine fumarate 286930-03-8 Neuroscience AChR 5-HMT antimuscarinic SPM-907 muscarinic mAChR overactive Fesoterodine Fumarate inhibit OAB Fesoterodine receptor SPM7605 Muscarinic acetylcholine receptor bladder Toviaz SPM 907 Desfesoterodine SPM907 Inhibitor orally inhibitor

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