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Desloratadine

Catalog No. T2520   CAS 100643-71-8
Synonyms: Sch34117, NSC 675447

Desloratadine (Sch34117) is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching and spasmodic contractions of gastrointestinal smooth muscle. Desloratadine is used to provide symptomatic relieve of allergic symptoms.

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Desloratadine Chemical Structure
Desloratadine, CAS 100643-71-8
Pack Size Availability Price/USD Quantity
25 mg In stock $ 35.00
50 mg In stock $ 46.00
100 mg In stock $ 63.00
200 mg In stock $ 101.00
500 mg In stock $ 241.00
1 g In stock $ 383.00
1 mL * 10 mM (in DMSO) In stock $ 52.00
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Purity: 100%
Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Desloratadine (Sch34117) is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching and spasmodic contractions of gastrointestinal smooth muscle. Desloratadine is used to provide symptomatic relieve of allergic symptoms.
Targets&IC50 Histamine H1 receptor:51 nM
Synonyms Sch34117, NSC 675447
Molecular Weight 310.82
Formula C19H19ClN2
CAS No. 100643-71-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 31.1 mg/mL (100 mM)

DMSO: 6.2 mg/mL (20 mM)

TargetMolReferences and Literature

1. 1. Cardelús I, et al. Eur J Pharmacol. 1999 Jun 18;374(2):249-54. 2. Geha RS, et al. J Allergy Clin Immunol, 2001, 107(4), 751-762. 3. Schroeder JT, et al. Clin Exp Allergy, 2001, 31(9), 1369-1377. 4. Anthes JC, et al. Eur J Pharmacol, 2002, 449(3), 229-237. 5. Howell G 3rd, et al. BMC Pharmacol, 2005, 5, 13. 6. Dong L, Shen S, Chen W, et al. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation[J]. Journal of chemical information and modeling. 2019, 59(10): 4374-4382.

TargetMolCitations

1. Dong L, Shen S, Chen W, et al. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation. Journal of chemical information and modeling. 2019, 59(10): 4374-4382. 2. Wang D, Guo Q, Wu Z, et al.Molecular mechanism of antihistamines recognition and regulation of the histamine H1 receptor.Nature Communications.2024, 15(1): 84.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Pediatric Drug Library Anti-Tumor Natural Product Library ReFRAME Related Library Anti-Obesity Compound Library Histamine & Melatonin Receptor-Targeted Compound Library Orally Active Compound Library

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Bilastine Metiamide Marmin Dioxopromethazine hydrochloride Ketotifen fumarate Cetirizine dihydrochloride Promethazine hydrochloride (±)-Tazifylline

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Keywords

Desloratadine 100643-71-8 GPCR/G Protein Immunology/Inflammation Metabolism Neuroscience Endogenous Metabolite Histamine Receptor NSC675447 Sch 34117 inhibit Sch34117 Sch-34117 NSC 675447 Inhibitor NSC-675447 inhibitor

 

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