Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum. With IC50 values of 8 nM, 4 nM and 3 nM, respectively. It has antiallergic activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 1,520.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 |
Description | AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum. With IC50 values of 8 nM, 4 nM and 3 nM, respectively. It has antiallergic activities. |
Targets&IC50 | LTE4:3 nM (in isolated guinea pig ileum), LTD4:4 nM (in isolated guinea pig ileum), LTC4:8 nM (in isolated guinea pig ileum) |
In vitro | In the trachea, the agent counteracts LTD4 and LTE4-induced contractions, exhibiting IC50 values of 10 nM and 20 nM, respectively. Additionally, in isolated guinea pig ileum preparations, AS-35 effectively opposes contractions induced by LTC4, LTD4, and LTE4, with respective IC50 values of 8 nM, 4 nM, and 3 nM. Notably, AS-35 does not inhibit LTC4-induced tracheal contractions when L-serine borate is present[1]. |
In vivo | AS-35, administered orally (p.o.), effectively suppresses the increase in cutaneous vascular permeability in guinea pigs caused by LTD4[1]. It also combats both LTD4 and antigen-induced leukotriene-mediated bronchoconstriction when given orally. Furthermore, intravenous (i.v.) doses of AS-35 ranging from 0.0375 to 0.3 mg/kg counteract bronchoconstriction caused by intravenously injected LTC4 and LTD4 in anesthetized guinea pigs in a dose-dependent manner, without affecting histamine-induced bronchoconstriction. |
Molecular Weight | 420.42 |
Formula | C21H20N6O4 |
CAS No. | 108427-72-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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AS-35 108427-72-1 Others AS 35 AS35 inhibitor inhibit