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Endocrinology/Hormones Oxytocin Receptor Atosiban acetate (90779-69-4 free base)

Atosiban acetate (90779-69-4 free base)

Catalog No. T5148   CAS 914453-95-5
Synonyms: Atosiban acetate, RW22164, RWJ22164, RWJ22164, RW22164, Atosiban acetate,

Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.

Atosiban acetate (90779-69-4 free base), CAS 914453-95-5
Pack Size Availability Price/USD Quantity
5 mg In stock 72.00
10 mg In stock 120.00
50 mg In stock 217.00
100 mg In stock 282.00
1 mL * 10 mM (in DMSO) In stock 139.00
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Purity 99.92%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
Targets&IC50 Others
Synonyms Atosiban acetate , RW22164 , RWJ22164 , RWJ22164 , RW22164 , Atosiban acetate ,
Purity 99.92%
Molecular Weight 1054.24
Formula C45H71N11O14S2
CAS No. 914453-95-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Akerlund M, et al. The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin. Acta Obstet Gynecol Scand. 1985;64(6):499-504.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Macrocyclic Compound Library Peptide Compound Library

Related Products

Related compounds with same targets
LIT-001 Oxytocin acetate (50-56-6 free base) Atosiban acetate (90779-69-4 free base) Carbetocin Carbetocin acetate(37025-55-1 free base)

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