store at low temperture,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban acetate (RW22164) suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 67.00 | |
10 mg | In stock | $ 117.00 | |
25 mg | In stock | $ 178.00 | |
50 mg | In stock | $ 217.00 | |
100 mg | In stock | $ 282.00 | |
500 mg | In stock | $ 695.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 136.00 |
Description | Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban acetate (RW22164) suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence. |
Synonyms | RW22164, Atosiban acetate (90779-69-4 free base), RWJ22164 |
Molecular Weight | 1054.24 |
Formula | C45H71N11O14S2 |
CAS No. | 914453-95-5 |
store at low temperture,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
You can also refer to dose conversion for different animals. More
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Atosiban acetate 914453-95-5 Endocrinology/Hormones GPCR/G Protein Oxytocin Receptor Vasopressin Receptor RWJ 22164 nonapeptide RW22164 Preterm vasopressin RW 22164 Atosiban tocolytic desamino-oxytocin inhibit Ca2+ oxytocin maternal-fetal Atosiban Acetate 90779-69-4 free base Atosiban acetate (90779-69-4 free base) RWJ22164 Inhibitor RWJ-22164 90779-69-4 RW-22164 OXTR inhibitor