colitis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2S0342	Armillarisin A		Others , Interleukin
	Armillarisin A enhancing the role of macrophages, inhibiting bacteria growth, improving the protein metabolism, and regulating liver function.		Others , Interleukin
T22344	Icatibant Acetate		Bradykinin Receptor
	Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.		Bradykinin Receptor
T35664	Tetracosactide acetate		Others
	Cosyntropin (acetate) stimulates the release of corticosteroids such as cortisol from the adrenal gland.		Others
T6S1027	Tussilagone		Others
	1. Tussilagone inhibits dendritic cell function through the induction of heme oxygenase-1. 2. Tussilagone has anti-cancer activity, might be a potential chemotherapeutic agent for the prevention and treatment of human co...		Others
T20615	Olsalazine	Dipentium,Salicylic acid	Others
	Olsalazine (Dipentium), an anti-inflammatory drug, is used in the treatment of inflammatory bowel disease. It is also a novel DNA hypomethylating agent.		Others
T10831L	Cl-amidine hydrochloride		Apoptosis , PAD
	Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro ca...		Apoptosis , PAD
T9377	ASK1-IN-2		Apoptosis , ASK , MAPK
	ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis[1].		Apoptosis , ASK , MAPK
T30751	Carotegrast methyl	AJM300	Integrin
	Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.		Integrin
T64336	Izilendustat		HIF/HIF Prolyl-Hydroxylase
	Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis.		HIF/HIF Prolyl-Hydroxylase
TN1084	1,3,5,8-Tetrahydroxyxanthone	Desmethylbellidifolin	Anti-infection
	1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Gentianella acuta. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity. Dimethylbellidifolin show...		Anti-infection
T12079	ML604440		Proteasome
	ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.		Proteasome
T2718	Palmatine chloride		Others , Indoleamine 2,3-Dioxygenase (IDO) , Aurora Kinase
	Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.		Others , Indoleamine 2,3-Dioxygenase (IDO) , Aurora Kinase
T31482	Diloxanide	Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida	Parasite
	Diloxanide (RD3803) is an endomoeba insecticide. It is considered to be the luminal agent of choice for patients with mild enteroamoebiasis or asymptomatic cysts.		Parasite
T4084	Sibofimloc	VRT-1353385,Antibiotic-202,Antibiotic 202	Antibacterial , Antibiotic
	Sibofimloc (Antibiotic-202), an antibiotic compound, is used in treating bacterial infections.		Antibacterial , Antibiotic
T31964	Glycolithocholic acid	Lithocholic acid glycine conjugate,Lithocholylglycine	Others
	Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.		Others
T5S0802	Palmatine	Berbericinine,Burasaine	Indoleamine 2,3-Dioxygenase (IDO) , AChR , AChE , Aurora Kinase
	1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery,...
T2171	SEW2871	SEW2871	S1P Receptor , LPL Receptor
	SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an...		S1P Receptor , LPL Receptor
T8160	EGCG Octaacetate		Others , Antibacterial
	EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities.		Others , Antibacterial
T2525	Alosetron hydrochloride	Lotronex,GR 68755C,GR 68755,GR 68755X	5-HT Receptor
	Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system,...		5-HT Receptor
T3147	Pyrrolidinedithiocarbamate ammonium	PDTC,Pyrrolidinedithiocarbamate,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate	NF-κB
	Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.		NF-κB