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Palmatine

Catalog No. T5S0802 CAS 3486-67-7

Synonyms: Berbericinine, Burasaine, 黄藤素；巴马汀

1. Palmatine is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.

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Palmatine, CAS 3486-67-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	1. Palmatine is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.
Targets&IC50	BChE:6.84 μM, AChE:0.51 μM

Synonyms	Berbericinine, Burasaine, 黄藤素；巴马汀
Molecular Weight	352.409
Formula	C21H22NO4
CAS No.	3486-67-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 64 mg/mL (181.61 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hambright H G, Batth I S, Xie J, et al. Palmatine inhibits growth and invasion in prostate cancer cell: Potential role forrpS6/NFκB/FLIP[J]. Mol Carcinog, 2015, 54(10):1227-1234.

Citations

1. Song Y, Xu C, Li X, et al. Palmatine Alleviates LPS-Induced Acute Lung Injury Via Interfering the Interaction of TAK1 and TAB1. Biochemical Pharmacology. 2022 Aug;202:115120.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library GPCR Compound Library Traditional Chinese Medicine Monomer Library Tibetan medicine Compound Library Neurotransmitter Receptor Compound Library Inhibitor Library Anti-Gastroenteritis Natural Product Library Natural Product Library for HTS Anti-Tumor Natural Product Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

Methyl tridecanoate Vincosamide Arjunolic acid Epiberberine chloride AChE-IN-26 AChE/BChE-IN-10 Jatrorrhizine chloride 1-Naphthyl acetate

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a dilution calculation using the Tocris dilution calculator
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Palmatine 3486-67-7 代谢神经科学 AChE AChR Indoleamine 2,3-Dioxygenase (IDO) IDO-1 fulminant hepatic failure Inhibitor Aurora Kinase West Nile virus colitis NS2B-NS3 Crohn’s disease Berbericinine ulcerative Virus Protease IBD Apoptosis Inflammatory bowel disease Burasaine inhibit memory-enhancing inhibitor

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