clearance — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T31101	CRT0273750	CRT 0273750,CRT-0273750	PDE
	CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.		PDE
T13554	Arimoclomol maleate	BRX-220	HSP
	Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.		HSP
TQ0239	PF-06291874	Glucagon receptor antagonists-4	Glucagon Receptor
	PF-06291874 (Glucagon receptor antagonists-4) (Glucagon receptor antagonists-4) is a highly effective and orally active antagonist of the glucagon receptor.		Glucagon Receptor
T8364	Mebrofenin	SQ 26962	Others
	Mebrofenin (SQ 26962) is available as a ready to use the kit for radio-labeling with Tc-99m.Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to...		Others
T13553	Arimoclomol	BRX-220 free base	HSP
	Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS).		HSP
T30577	BRD0418	BRD 0418,BRD-0418	Others
	BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.		Others
T4398	LX2343		Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
	LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.		Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
T5S0658	Corynoxine		Autophagy
	Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla. It is an autophagy enhancer that promotes α-synuclein clearance through the Akt/mTOR pathway.		Autophagy
T50000	2-Iodohippuric Acid		Others
	2-Iodohippuric Acid can be used to measure renal clearance for renal function studies, and for the diagnosis of certain diseases, such as liver and kidney disease. In addition, it is used in the synthesis of certain drug...		Others
T7295	Miridesap	Ro63-8695,CPHPC,GSK2315698	Others
	Miridesap (GSK2315698) is a divalent crosslinker of SAP that causes rapid depletion of circulating SAP via hepatic clearance. It also produces significant reduction of SAP from cerebrospinal fluid and visceral amyloid de...		Others
T63056	Dovramilast
	Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor that reduces the inflammatory response and improves INH-mediated clearance of bacteria from the lung.Dovramilast (CC-11050) can be used as a...
T5117	Hexaflumuron		Others
	Hexaflumuron is a chitin synthesis inhibitor used to bait and eliminate termite colonies. Termites are unable to metabolize hexaflumuron and clearance is slow, resulting in up to 100% elimination. Hexaflumuron has also b...		Others
T9741	INE963		Others
	INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h. INE963 is also potent against P. falciparum and P....		Others
TN1420	Bacopaside I		Others
	Bacopaside I is a saponin isolated from Bacopa monniera. Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/PS1 ...		Others
T28449	Pradefovir	ICN-2001-3,MB-6866,ICN-20013,MB-06866,Remofovir	HBV
	Pradefovir (Remofovir) is a reverse transcriptase inhibitor potentially for treatment of chronic HBV infection. Pradefovir is also a liver-targeted prodrug of adefovir. After metabolic activation, Pradefovir was converte...		HBV
T3312	AM-2394	AM2394	Glucokinase
	AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximatel...		Glucokinase
TL0007	Bisdemethoxycurcumin	Curcumin III,Didemethoxycurcumin	Epigenetic Reader Domain , Wnt/beta-catenin
	Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by mac...		Epigenetic Reader Domain , Wnt/beta-catenin
T1415	Gemfibrozil	CI-719,Jezil,Decrelip,Lopid	P450 , Adrenergic Receptor , PPAR
	Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi...		P450 , Adrenergic Receptor , PPAR
T0920	Ambroxol	Ambroxolum,NA-872	P450 , Autophagy
	Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a muco...		P450 , Autophagy
T13667L	Dusquetide	SGX942	Others
	Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.		Others