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Arimoclomol maleate

Catalog No. T13554 CAS 289893-26-1

Synonyms: BRX-220

Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.

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Arimoclomol maleate, CAS 289893-26-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 147.00
50 mg	In stock	$ 247.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.98%

Purity: 99.9%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.

In vivo

Arimoclomol, administered for 5 d, has a protective effect against CCK-induced acute pancreatitis. Repeated CCK treatment results in the typical laboratory and morphological changes of experimentally induced pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased in the animals treated with Arimoclomol [1]. Arimoclomol is a co-inducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease [2].

Synonyms	BRX-220
Molecular Weight	429.85
Formula	C18H24ClN3O7
CAS No.	289893-26-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (581.60 mM), Sonification is recommended.

References and Literature

1. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92. 2. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Metabolism Disease Compound Library Anti-Breast Cancer Compound Library Immunology/Inflammation Compound Library NO PAINS Compound Library Metabolism Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compounds Library Max

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Keywords

Arimoclomol maleate 289893-26-1 Cytoskeletal Signaling Metabolism HSP system neurons Inhibitor motor clearance Arimoclomol BRX 220 Heat shock proteins aggregation ubiquitin BRX-220 misfolded inhibit protein BRX220 proteasome Arimoclomol Maleate assemblies co-inducer inhibitor

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