aortic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5458	Darusentan	Lu-135252	Endothelin Receptor
	Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries		Endothelin Receptor
TN1969	N-(p-Coumaroyl) serotonin		PDGFR
	N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving...		PDGFR
TQ0003	740 Y-P	740YPDGFR,PDGFR 740Y-P	PI3K , Autophagy
	740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.		PI3K , Autophagy
T3965	Fevipiprant	QAW039,NVP-QAW039	GPR , Prostaglandin Receptor
	Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.		GPR , Prostaglandin Receptor
T13475	β-Aminopropionitrile	3-Aminopropionitrile,BAPN	Others , Endogenous Metabolite
	β-Aminopropionitrile (3-Aminopropionitrile) is a selective inhibitor of lysyl oxidase.		Others , Endogenous Metabolite
T7437	3-(3-Hydroxyphenyl)propionic Acid	m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid	Others , Endogenous Metabolite
	3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) is one of the major metabolites of ingested caffeic acid.it inhibited osteoclastogenesis and bone osteoclastic resorptive activity.		Others , Endogenous Metabolite
T6991	Nitroprusside disodium dihydrate	Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate	Guanylate cyclase , Autophagy
	Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.		Guanylate cyclase , Autophagy
T10101	Calcium channel-modulator-1		Others , Calcium Channel
	Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction.		Others , Calcium Channel
T33868	Palmitoyl glutamic acid	N-Palmitoyl-L-glutamic acid,Palmitoylglutaminic acid
	Palmitoyl glutamic acid (N-Palmitoyl-L-glutamic acid) is an acyl amino acid that blocks aortic constriction and antagonizes haloperidol-induced oral motility disorders.
T62893	SM-2470		Adrenergic Receptor
	SM-2470 is an α1-adrenoceptor antagonist with antihypertensive activity that decreases anterior ganglionic adrenal nerve activity and aortic descending nerve activity.SM-2470 has hypocholesterolemic activity and inhibits...		Adrenergic Receptor
TQ0057	AVE 0991		Others
	AVE 0991, a nonpeptide analog of angiotensin-(1-7) [Ang-(1-7)], is an orally active Mas agonist with inhibitory effects on [125I]-Ang-(1-7) binding to bovine aortic endothelial cell membranes, and inhibits astrocyte-medi...		Others
T6102	2'-acetylacteoside		Antioxidant , Reductase
	2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-Acetylacteoside shows antiproliferative effects on aortic smoo...		Antioxidant , Reductase
T11598	IAXO-102		TLR
	IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdomin...		TLR
T7284	Argipressin acetate (113-79-1(free base))		Others
	Vasopressin acetate is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle...		Others
T11076	Dooku1		Others
	Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yod...		Others
T30140	Arotinolol hydrochloride	Arotinolol HCl	5-HT Receptor , Adrenergic Receptor
	Arotinolol hydrochloride（Arotinolol HCl） is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol h...		5-HT Receptor , Adrenergic Receptor
TN1724	Harmalol hydrochloride	Harmidol hydrochloride	P450 , Antioxidant
	Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits ...		P450 , Antioxidant
T68123	Oxodipine		Calcium Channel
	Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventri...		Calcium Channel
T33440	MK785	MK-785,MK 785
	MK785 is part of the association between inhibition of aortic histamine formation, aortic albumin permeability, and atherosclerosis. Aortic histamine synthesis was inhibited by partial inhibition of aortic histidine deca...
T32406	KMUP-4	KMUP 4
	Kmup-4 is an enhancer of cGMP activity and an aortic smooth muscle relaxant.