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Arotinolol hydrochloride

Catalog No. T30140 CAS 68377-91-3

Synonyms: Arotinolol HCl

Arotinolol hydrochloride（Arotinolol HCl） is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol hydrochloride is an antihypertensive and anti-obesity agent that improves aortic stiffness in rats and is used to study obesity-related diseases.

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Arotinolol hydrochloride Chemical Structure

Arotinolol hydrochloride, CAS 68377-91-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
5 mg	In stock	$ 108.00
10 mg	In stock	$ 162.00
25 mg	In stock	$ 268.00
50 mg	In stock	$ 392.00
100 mg	In stock	$ 588.00
500 mg	In stock	$ 1,250.00

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Purity: 99.84%

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Description	Arotinolol hydrochloride（Arotinolol HCl） is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol hydrochloride is an antihypertensive and anti-obesity agent that improves aortic stiffness in rats and is used to study obesity-related diseases.
In vitro	Arotinolol HCl shows its potency for inhibiting the binding of the same radioligand to the 5HT1B-serotonergic receptor site, Arotinolol HCl displaces 125I-ICYP binding to 5HT1B-receptors with the pKi values of 7.97 and 8.16 respectively for β1 and β2 adrenergic receptors.[3] Arotinolol HCl shows its selectivity of β-adrenergic receptors, the result of Arotinolol HCl for β1 and β2 adrenoceptors in 125I-ICYP binding to rat cerebral cortical membranes with pKi value of 9.74 and 9.26 respectively. The selective of β1 and β2 is equal.[3]
In vivo	Arotinolol HCl (200 mg/kg; oral gavage; 8 weeks) can significantly decrease central arterial pressure (CAP) and pulse wave velocity (PWV), in addition, it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mice.[3]

Synonyms	Arotinolol HCl
Molecular Weight	408
Formula	C15H22ClN3O2S3
CAS No.	68377-91-3

Storage

store under nitrogen

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wang Z, et al. Magnetic solid-phase extraction based on magnetic multiwalled carbon nanotubes for the simultaneous enantiomeric analysis of five β-blockers in the environmental samples by chiral liquid chromatography coupled with tandem mass spectrometry. Talanta. 2018 Apr 1;180:98-107. 2. Qian Z, et al. High-throughput LC-MS/MS method with 96-well plate precipitation for the determination of arotinolol and amlodipine in a small volume of rat plasma: Application to a pharmacokinetic interaction study. J Sep Sci. 2018 Feb;41(3):618-629. 3. Zhou W, et al. Mechanisms of improved aortic stiffness by arotinolol in spontaneously hypertensive rats. PLoS One. 2014 Feb 12;9(2):e88722. 4. TSUCHIHASHI H, et al. Characteristics of 125I-lodocyanopindolol Binding to β-Adrenergic and Serotonin-1B Receptors of Rat Brain: Selectivity of β-Adrenergic Agents. The Japanese Journal of Pharmacology.1990, 52(2): 195-200.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max Approved Drug Library

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Keywords

Arotinolol hydrochloride 68377-91-3 GPCR/G Protein Neuroscience Adrenergic Receptor 5-HT Receptor Arotinolol HCl Arotinolol Hydrochloride inhibitor inhibit

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