anti-osteoporosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T61269	Anti-osteoporosis agent-1
	Anti-osteoporosis agent-1 (comp 4aa) is an effective RPA (replication protein A) inhibitor, demonstrating potency with an IC50 value of 18 μM [1].
T39508	KY-02327		Others
	KY-02327, a metabolically stabilized analog of KY-02061, serves as a potent inhibitor of the Dishevelled (Dvl)-CXXC5 interaction. This compound activates the Wnt/β-catenin pathway, thereby promoting osteoblast differenti...		Others
T83032	Anti-osteoporosis agent-7
	Compound 133, also known as Anti-osteoporosis agent-7, is a potential anti-osteoporosis agent that exhibits significant inhibition of osteoclast formation.
T83033	Anti-osteoporosis agent-2
	Anti-osteoporosis agent-2 (Compound 10) serves as an inhibitor of osteoclast differentiation induced by RANKL [1].
T78816	Anti-osteoporosis agent-4		NF-κB
	Anti-osteoporosis agent-4 (Compound 11h) suppresses the differentiation of primary osteoclasts and attenuates RANKL-induced osteoclastogenesis. It effectively inhibits osteoclast formation, demonstrating an IC50 value of...		NF-κB
T3408	Syringin	Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine	NOS , Autophagy
	Syringin (eleutheroside-b) is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.		NOS , Autophagy
T6739	Zoledronic Acid	CGP-4244,CGP42446A,Zoledronate,CGP 42446,ZOL 446,Zometa	Apoptosis , Rho , Autophagy
	Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalc...		Apoptosis , Rho , Autophagy
T21299	Zoledronic acid monohydrate	zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate	Apoptosis , Others , Autophagy
	Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.		Apoptosis , Others , Autophagy
T3906	Epimedin A		Others
	Epimedin A has anti-osteoporosis activities in vivo.		Others
T3396	Baohuoside I	Icariside-II,Icariin-II	Apoptosis , CXCR
	Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.		Apoptosis , CXCR
T6S2252	Sweroside		Others
	1. Sweroside possesses strong hepatoprotective effect. 2. Sweroside is a promising osteoporosis therapeutic natural product, has anti-osteoporotic effect on the human MG-63 cells and rat osteoblasts.		Others
T67855	ISX-3		Others
	ISX-3 is a potent pro-osteogenic and anti-adipogenic agent. ISX-3 can increase the expression of PPARγ. ISX-3 can be for the research of osteopenia and osteoporosis.		Others
T2768	Saikosaponin A		NF-κB , Antibacterial , Liver X Receptor
	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath...		NF-κB , Antibacterial , Liver X Receptor
T3S0364	L-Arginine	L-Arg,(S)-(+)-Arginine	IL Receptor , Endogenous Metabolite , NO Synthase
	1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. 3. Exogenous L-Arginine could enhance neonate...		IL Receptor , Endogenous Metabolite , NO Synthase
TN5888	Toddaculin		Others
	Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in...		Others
T6S2099	Geraniin		Antioxidant , TNF
	1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation ...		Antioxidant , TNF
T81761	Morusignin L
	Morusignin L, an active compound, exhibits anti-osteoporosis properties [1] [2].
T78278	Blosozumab
	Blosozumab (LY2541546), an anti-sclerostin (SOST) antibody, promotes bone formation while decreasing bone resorption, with potential applications in osteoporosis research [1] [2].
TN1431	Baohuoside VII		Others
	Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VI...		Others
TN3144	6,4'-Dihydroxy-7-methoxyflavanone		ERK , IL Receptor , Antioxidant , TNF , NF-κB , MAPK , Prostaglandin Receptor , JNK , Autophagy
	6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy...