xiap — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T64161	XIAP degrader-1
	XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP).
T79483	MDM2/XIAP-IN-3
	MDM2/XIAP-IN-3 (compound 3e), a dual inhibitor of MDM2/XIAP, diminishes MDM2 and XIAP protein levels while augmenting p53 expression, consequently suppressing cancer cell proliferation and inducing apoptosis [1].
T64302	XIAP/cIAP1 antagonist-1
	XIAP/cIAP1 antagonist-1 is a potent, orally active XIAP/cIAP1 antagonist that acts on XIAP (EC50: 5.1 nM) and cIAP1 (EC50: 0.32 nM). xIAP/cIAP1 antagonist-1 dose-dependently inhibits tumour growth in vivo.
T81830	MDM2/XIAP-IN-1
	MDM2/XIAP-IN-1 (compound 14) is an orally active dual inhibitor of MDM2 and XIAP, exhibiting anti-cancer activity with an IC50 of 0.3 μM and potential applications in cancer research [1].
T79012	MDM2/XIAP-IN-2
	MDM2/XIAP-IN-2 is a dual inhibitor targeting murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). It promotes the degradation of MDM2 and impedes translation of XIAP mRNA, effectively inhibit...
T16522	Phenoxodiol	Dehydroequol,Idronoxil,Haginin E	Apoptosis , IAP , Caspase , Topoisomerase , p53
	Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apop...		Apoptosis , IAP , Caspase , Topoisomerase , p53
T2080	LCL161		IAP
	LCL161, a SMAC mimetic, effectivity binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).		IAP
T14378L	AZD5582 acetate (1258392-53-8 free base)		IAP
	AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis.		IAP
T36201L	AZD5582 TFA	AZD5582 TFA（1258392-53-8 free base）	Apoptosis , IAP
	AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFA induces apoptosis.		Apoptosis , IAP
T3653	MX69		Mdm2 , E1/E2/E3 Enzyme , IAP
	MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.		Mdm2 , E1/E2/E3 Enzyme , IAP
TQ0029	ASTX660		IAP
	ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP.		IAP
T12932L	SM-164		Apoptosis , IAP
	SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP.		Apoptosis , IAP
T6763	Xevinapant	ARRY-334543,SM-406,AT406,Debio-1143	IAP
	Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, ...		IAP
T6428	BV6		IAP
	BV6 is an antagonist of c-IAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.		IAP
T6299	GDC-0152	GDC0152	IAP
	GDC-0152 is a potent inhibitor of IAPs.		IAP
T3867	Alpinetin	(-)-alpinetin	BCL , PPAR
	Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-he...		BCL , PPAR
T3884	Neoandrographolide	Neoandrographiside	NOS , COX
	Neoandrographolide (Neoandrographiside) has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory effect, might result from inhibition of iN...		NOS , COX
T6485	Embelin	NSC 91874,Emberine,Embelic acid	Apoptosis , NF-κB , Lipoxygenase , IAP , Prostaglandin Receptor , Autophagy
	Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T6007	Birinapant	TL32711	Apoptosis , IAP , HIV Protease
	Birinapant (TL32711) is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with po...		Apoptosis , IAP , HIV Protease
T12932	SM-164 Hydrochloride (957135-43-2 free base)	SM-164 Hydrochloride	IAP
	SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains(IC50 value of 1.39 nM) and functions as an extremely potent antagonist of XIAP.		IAP