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Phenoxodiol

Catalog No. T16522   CAS 81267-65-4
Synonyms: Dehydroequol, Idronoxil, Haginin E

Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Phenoxodiol also inhibits DNA topoisomerase II.

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Phenoxodiol Chemical Structure
Phenoxodiol, CAS 81267-65-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 60.00
2 mg In stock $ 88.00
5 mg In stock $ 147.00
10 mg In stock $ 239.00
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1 mL * 10 mM (in DMSO) In stock $ 162.00
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Purity: 98.07%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Phenoxodiol also inhibits DNA topoisomerase II.
In vitro Phenoxodiol, at concentrations >or=1 microg/ml (4 microM), inhibited proliferation and reduced the viability of healthy donor-derived PBMC. In contrast, lower Phenoxodiol concentrations (0.05-0.5 microg/ml) augmented, upon 3-day incubation, peripheral blood mononuclear cells cytotoxicity. Experiments with purified CD56(+) lymphocytes revealed that Phenoxodiol enhanced the lytic function of natural killer cells by directly stimulating this lymphocytic subpopulation[3].
In vivo Balb/C mice administered low-dose Phenoxodiol exhibited significantly reduced tumour growth rates and prolonged survival (in 40% of the animals) in a colon cancer model[3].
Synonyms Dehydroequol, Idronoxil, Haginin E
Molecular Weight 240.25
Formula C15H12O3
CAS No. 81267-65-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (208.12 mM)

TargetMolReferences and Literature

1. Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14(1):110. 2. Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22(17):2611-20. 3. Georgaki S, et al. Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo. J Cell Mol Med. 2009 Sep;13(9B):3929-38.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Bioactive Compounds Library Max Human Metabolite Library Protease Inhibitor Library Mitochondria-Targeted Compound Library Anti-Cancer Compound Library Clinical Compound Library Drug Repurposing Compound Library

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Keywords

Phenoxodiol 81267-65-4 Apoptosis DNA Damage/DNA Repair Proteases/Proteasome IAP Caspase Topoisomerase p53 inhibit Inhibitor XIAP CP70 Dehydroequol Idronoxil Haginin E ovarian cancer prostate cancer inhibitor

 

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