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Search Results for " notch "

20

Compounds

Cat No. Product Name Synonyms Targets
T16341 Notch inhibitor 1 Others
Notch inhibitor 1 is an effective Notch inhibitor (IC50s: 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively). Notch inhibitor 1 is also used in the research of cancer.
T19483 Notch 1 TFA Others
Notch 1 TFA encodes a member of the NOTCH family of proteins.
T3540 IMR-1A Gamma-secretase , Drug Metabolite
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
T12246 CB-103 Gamma-secretase
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
T6861 IMR-1 Gamma-secretase
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.
T3075 FLI-06 FLI 06 Gamma-secretase
FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).
T6063 LY-411575 LY411575 Apoptosis , Gamma-secretase
LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM.
TWS2045 Bruceine D Apoptosis , Antiviral , Gamma-secretase , Parasite
1. Bruceine D from Brucea javanica, may have the potential to be used as a natural viricide, or a lead compound for new viricides. 2. Bruceine D inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW...
T6249 Avagacestat BMS-708163 Gamma-secretase
Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
T3633 Crenigacestat LY3039478 Gamma-secretase
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo...
T3399 Psoralidin Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
T6202 DAPT LY-374973,GSI-IX Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.
T6274 RO4929097 RG-4733 Beta Amyloid , Gamma-secretase
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
T4S1990 Carvacrol Karvakrol,O-Thymol,cymophenol Apoptosis , Others , Gamma-secretase , Endogenous Metabolite , Antifungal
1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effects, seems to be dependent on its interaction with the dopami...
T6125 Semagacestat LY450139 Beta Amyloid , Gamma-secretase
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
T13410 ZLDI-8 Apoptosis , Phosphatase , Gamma-secretase , Immunology/Inflammation related
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T2842 Tangeretin NSC53909,Tangeritin,NSC618905 Apoptosis , Gamma-secretase
Tangeretin (NSC-618905), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models and was also selected as a Notc...
T6135 YO-01027 gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ Gamma-secretase
YO-01027 (DBZ) is a potent γ-secretase inhibitor.
T22678 3,5-Bis(4-nitrophenoxy)benzoic acid Compound W Gamma-secretase
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
T6935 Nirogacestat PF-03084014,PF-3084014,PF03084014,PF 03084014 Apoptosis , Gamma-secretase
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).

Compounds

Notch inhibitor 1
T16341
Synonym:
Target: Others
Notch 1 TFA
T19483
Synonym:
Target: Others
IMR-1A
T3540
Synonym:
Target: Gamma-secretase, Drug Metabolite
CB-103
T12246
Synonym:
Target: Gamma-secretase
IMR-1
T6861
Synonym:
Target: Gamma-secretase
FLI-06
T3075
Synonym: FLI 06
Target: Gamma-secretase
LY-411575
T6063
Synonym: LY411575
Target: Apoptosis, Gamma-secretase
Bruceine D
TWS2045
Synonym:
Target: Apoptosis, Antiviral, Gamma-secretase, Parasite
Avagacestat
T6249
Synonym: BMS-708163
Target: Gamma-secretase
Crenigacestat
T3633
Synonym: LY3039478
Target: Gamma-secretase
Psoralidin
T3399
Synonym:
Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial
DAPT
T6202
Synonym: LY-374973,GSI-IX
Target: Apoptosis, Beta Amyloid, Gamma-secretase, Autophagy
RO4929097
T6274
Synonym: RG-4733
Target: Beta Amyloid, Gamma-secretase
Carvacrol
T4S1990
Synonym: Karvakrol,O-Thymol,cymophenol
Target: Apoptosis, Others, Gamma-secretase, Endogenous Metabolite, Antifungal
Semagacestat
T6125
Synonym: LY450139
Target: Beta Amyloid, Gamma-secretase
ZLDI-8
T13410
Synonym:
Target: Apoptosis, Phosphatase, Gamma-secretase, Immunology/Inflammation related
Tangeretin
T2842
Synonym: NSC53909,Tangeritin,NSC618905
Target: Apoptosis, Gamma-secretase
YO-01027
T6135
Synonym: gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ
Target: Gamma-secretase
3,5-Bis(4-nitrophenoxy)benzoic acid
T22678
Synonym: Compound W
Target: Gamma-secretase
Nirogacestat
T6935
Synonym: PF-03084014,PF-3084014,PF03084014,PF 03084014
Target: Apoptosis, Gamma-secretase
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TargetMol