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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16341 | Notch inhibitor 1 | Others | |
Notch inhibitor 1 is an effective Notch inhibitor (IC50s: 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively). Notch inhibitor 1 is also used in the research of cancer. | |||
T19483 | Notch 1 TFA | Others | |
Notch 1 TFA encodes a member of the NOTCH family of proteins. | |||
T3540 | IMR-1A | Gamma-secretase , Drug Metabolite | |
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. | |||
T12246 | CB-103 | Gamma-secretase | |
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity. | |||
T6861 | IMR-1 | Gamma-secretase | |
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. | |||
T3075 | FLI-06 | FLI 06 | Gamma-secretase |
FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM). | |||
T6063 | LY-411575 | LY411575 | Apoptosis , Gamma-secretase |
LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM. | |||
TWS2045 | Bruceine D | Apoptosis , Antiviral , Gamma-secretase , Parasite | |
1. Bruceine D from Brucea javanica, may have the potential to be used as a natural viricide, or a lead compound for new viricides. 2. Bruceine D inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW... | |||
T6249 | Avagacestat | BMS-708163 | Gamma-secretase |
Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. | |||
T3633 | Crenigacestat | LY3039478 | Gamma-secretase |
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo... | |||
T3399 | Psoralidin | Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial | |
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties. | |||
T6202 | DAPT | LY-374973,GSI-IX | Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy |
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis. | |||
T6274 | RO4929097 | RG-4733 | Beta Amyloid , Gamma-secretase |
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM). | |||
T4S1990 | Carvacrol | Karvakrol,O-Thymol,cymophenol | Apoptosis , Others , Gamma-secretase , Endogenous Metabolite , Antifungal |
1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effects, seems to be dependent on its interaction with the dopami... | |||
T6125 | Semagacestat | LY450139 | Beta Amyloid , Gamma-secretase |
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM). | |||
T13410 | ZLDI-8 | Apoptosis , Phosphatase , Gamma-secretase , Immunology/Inflammation related | |
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein. | |||
T2842 | Tangeretin | NSC53909,Tangeritin,NSC618905 | Apoptosis , Gamma-secretase |
Tangeretin (NSC-618905), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models and was also selected as a Notc... | |||
T6135 | YO-01027 | gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ | Gamma-secretase |
YO-01027 (DBZ) is a potent γ-secretase inhibitor. | |||
T22678 | 3,5-Bis(4-nitrophenoxy)benzoic acid | Compound W | Gamma-secretase |
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). | |||
T6935 | Nirogacestat | PF-03084014,PF-3084014,PF03084014,PF 03084014 | Apoptosis , Gamma-secretase |
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay). |