mt-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16156	MT 63-78		Apoptosis , AMPK , mTOR
	MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel...		Apoptosis , AMPK , mTOR
T7519	RS-127445 hydrochloride	RS 127445,MT 500	5-HT Receptor
	RS-127445 hydrochloride (MT 500) is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5).		5-HT Receptor
T39461	MT1
	MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).
T11465	Lenacapavir	GS-6207	Others , HIV Protease
	Lenacapavir (GS-6207) is a potent capsid-targeting inhibitor of HIV replication. Lenacapavir shows anti-HIV activity with an EC50 of 100 pM in MT-4 cells.		Others , HIV Protease
T61569	Mt KARI-IN-1
	Mt KARI-IN-1 is a lead compound that demonstrates strong inhibitory activity towards Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), with a Ki value of 3.06 μM [1].
T10305	Amiselimod hydrochloride	MT-1303 hydrochloride	S1P Receptor , LPL Receptor
	Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.		S1P Receptor , LPL Receptor
T16157	MT-802		BTK , PROTACs
	MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).		BTK , PROTACs
TQ0174	Mavorixafor	AMD-070	CXCR
	Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC...		CXCR
T67833	HIV-1 inhibitor-54		HIV Protease
	HIV-1 inhibitor-54 is a potent HIV-1 inhibitor showing anti-HIV activity (EC50 : 32 nM) against WT HIV-1 (strain IIIB) x in MT-4 cells.HIV-1 inhibitor-54 can be used to study viral infections.		HIV Protease
T17319	1,2-Bis(2-iodoethoxy)ethane		Others , PROTAC Linker
	1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 and SJF620. MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, res...		Others , PROTAC Linker
T4S1521	1,4-Dicaffeoylquinic acid		HIV Protease
	1,4-Dicaffeoylquinic acid has antioxidant activity.1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 replication in MT-2 cell culture at non-toxic concentration...		HIV Protease
T25310	Dersimelagon	MT-7117	Melanocortin Receptor
	Dersimelagon (MT-7117) is an orally active, selective agonist for the melanocortin 1 receptor (MC1R), demonstrating EC50 values of 8.16 nM (h), 3.91 nM (cm), 1.14 nM (m), and 0.251 nM (r) across species such as human, cy...		Melanocortin Receptor
T7208	AMD 3465 hexahydrobromide	GENZ-644494 (hexahydrobromide)	HIV Protease , CXCR
	AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.		HIV Protease , CXCR
T60490	Melatonin receptor agonist 1
	Melatonin receptor agonist 1 (compound 20c) is a potent agonist of melatonin receptor (MT) with Ki values of 108 nM for MT2 and 1140 nM for MT 1 [1].
T10296	Mavorixafor trihydrochloride	AMD-070 trihydrochloride	HIV Protease
	Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (I...		HIV Protease
T82438	Etedesiran
	Etedesiran acts as an inhibitor of Myotonin-protein kinase (MT-PK, MDPK, or DMPK) [1].
T11693L	IT1t dihydrochloride		CXCR
	IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.		CXCR
T79029	IpOHA
	IpOHA is a potent inhibitor of plant KARI and functions as an antimycobacterial agent, demonstrating a K_i value of 97.7 nM against Mycobacterium tuberculosis (Mt) [1].
T61570	Mt KARI-IN-2
	Mt KARI-IN-2 (compound 5b) is a highly effective inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), with a Ki value of 2.02 μM. This compound also exhibits inhibitory activity against Mtb H37...
T62782	HIV-1 inhibitor-34
	HIV-1 inhibitor-34 (compound 5q) is a potent, selective HIV-1 inhibitor that acts on HIV-1 (EC50: 6.4 nM), MT-4 cells (CC50: 16 μM). HIV-1 inhibitor-34 can be used in AIDS research.