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AMD 3465 hexahydrobromide

AMD 3465 hexahydrobromide
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.
Catalog No. T7208Cas No. 185991-07-5
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Purity:99.03%
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AMD 3465 hexahydrobromide

Catalog No. T7208Cas No. 185991-07-5
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$31In Stock
10 mg$43In Stock
25 mg$85In Stock
50 mg$146In Stock
100 mg$230In Stock
200 mg$342In Stock
1 mL x 10 mM (in DMSO)$37In Stock
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Product Introduction

Bioactivity
Description
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.
Targets&IC50
X4 HIV-1 (NL4.3):6.1 nM (IC50, in MT-4 cells), 12G5 mAb-CXCR4:0.75 nM (IC50, in SupT1 cells), X4 HIV-1 (HE):9.8 nM (IC50, in MT-4 cells), CXCL12 (AF647)-CXCR4:18 nM (IC50, in SupT1 cells), X4 HIV-1 (NL4.3AMD3100):2822 nM (IC50, in MT-4 cells), HIV-2 (EHO):12.3 nM (IC50, in MT-4 cells), HIV-2 (ROD):12.3 nM (IC50, in MT-4 cells), X4 HIV-1 (IIIB):12.3 nM (IC50, in MT-4 cells), X4 HIV-1 (RF):7.4 nM (IC50, in MT-4 cells)
In vitro
AMD 3465 hexahydrobromide inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells.?AMD 3465 (50 nM) totally blocks CXCL12-induced calcium mobilization, with an IC50 of 17 nM, but shows no effect on the intracellular calcium fluxes elicited by the CCR5 ligands RANTES, LD78β and MIP-1β in U87.CD4.CCR5 cells.?AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.?AMD3465 is cytotoxic to the X4 HIV-1 strains IIIB, NL4.3, RF and HE with an IC50 ranging from 6 to 12 nM.?The IC50 for suppression of the HIV-2 strains ROD and EHO is 12.3 nM[1].?AMD 3465 inhibits CXCL-12-induced growth in U87 and Daoy cells.?AMD 3465 treatment stimulates the phosphorylation of Erk1/2 in U87 and Daoy cells[2].
In vivo
Administering 2.5 mg/kg/d of AMD 3465 subcutaneously for five weeks significantly inhibits the growth of U87 glioblastoma multiforme (GBM) and Daoy medulloblastoma xenografts.
AliasGENZ-644494 (hexahydrobromide)
Chemical Properties
Molecular Weight896.07
FormulaC24H44Br6N6
Cas No.185991-07-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 38 mg/mL (42.41 mM)
DMSO: 50 mg/mL (55.80 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.1160 mL5.5799 mL11.1598 mL55.7992 mL
5 mM0.2232 mL1.1160 mL2.2320 mL11.1598 mL
10 mM0.1116 mL0.5580 mL1.1160 mL5.5799 mL
20 mM0.0558 mL0.2790 mL0.5580 mL2.7900 mL
DMSO
1mg5mg10mg50mg
50 mM0.0223 mL0.1116 mL0.2232 mL1.1160 mL

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