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MT-802

MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).

Catalog No. T16157Cas No. 2231744-29-7

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Purity:97%

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COA HPLC HNMR

MT-802

Catalog No. T16157Cas No. 2231744-29-7

MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$88	In Stock
5 mg	$197	In Stock
10 mg	$298	In Stock
25 mg	$567	In Stock
50 mg	$768	In Stock
100 mg	$987	In Stock
200 mg	$1,390	In Stock
1 mL x 10 mM (in DMSO)	$257	In Stock

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Product Introduction

Bioactivity

Description	MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).
Targets&IC50	BTK:1 nM(DC50)
In vitro	MT-802 degrades BTK (DC50: 9.1 nM). The maximal degradation was observed by 250 nM.

Chemical Properties

Molecular Weight	787.82
Formula	C₄₁H₄₁N₉O₈
Cas No.	2231744-29-7

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (126.93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2693 mL	6.3466 mL	12.6933 mL	63.4663 mL
5 mM	0.2539 mL	1.2693 mL	2.5387 mL	12.6933 mL
10 mM	0.1269 mL	0.6347 mL	1.2693 mL	6.3466 mL
20 mM	0.0635 mL	0.3173 mL	0.6347 mL	3.1733 mL
50 mM	0.0254 mL	0.1269 mL	0.2539 mL	1.2693 mL
100 mM	0.0127 mL	0.0635 mL	0.1269 mL	0.6347 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc