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Mavorixafor

Mavorixafor
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Purity:98.56%
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Mavorixafor

Catalog No. TQ0174Cas No. 558447-26-0
Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC50 = 1 nM) and PBMCs (IC50 = 9 nM).
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Pack SizePrice/USDAvailabilityQuantity
1 mg$64In Stock
2 mg$93In Stock
5 mg$155In Stock
10 mg$232In Stock
25 mg$417In Stock
50 mg$619In Stock
100 mg$879In Stock
1 mL x 10 mM (in DMSO)$262In Stock
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Product Introduction

Bioactivity
Description
Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC50 = 1 nM) and PBMCs (IC50 = 9 nM).
In vitro
Mavorixafor (6.6 µM) significantly decreases the anchorage-dependent growth, migration, and matrigel invasion of the B88-SDF-1 cells [1]. Mavorixafor shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2) [2].
In vivo
AMD-070 (2 mg/kg, p.o.) markedly decreases the quantity of metastatic lung nodules in mice and reduces human Alu DNA expression without causing weight loss [1].
Cell Research
Cells are seeded on a 96-well plate at 5 × 10^3 cells/well in DMEM containing 10% FCS. Twenty-four hours later, the cells are treated with or without 2 µM AMD3100 or 6.6 µM AMD-070. After 24 or 48 h, the number of cells is quantified by an assay using MTT [2].
Animal Research
BALB/c nude mice are maintained under pathogen-free conditions. The experiments are initiated when the mice are 8 weeks of age. Briefly, the cells are inoculated into the blood vessels of nude mice (1× 10^6). These mice are sacrificed at day 49. The presence or absence of distant metastases is confirmed by hematoxylin and eosin (H&E) staining. For experimental chemotherapy, the mice are treated by the daily oral administration of 0.2 mL of saline for a vehicle or the same volume of AMD-070 (2 mg/kg) [2].
AliasAMD-070
Chemical Properties
Molecular Weight349.47
FormulaC21H27N5
Cas No.558447-26-0
Storage & Solubility Information
Storagestore under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 44 mg/mL (125.9 mM)
H2O: 7 mg/mL (20.03 mM)
DMSO: 17 mg/mL (48.64 mM)
Solution Preparation Table
Ethanol/H2O
1mg5mg10mg50mg
1 mM2.8615 mL14.3074 mL28.6148 mL143.0738 mL
5 mM0.5723 mL2.8615 mL5.7230 mL28.6148 mL
10 mM0.2861 mL1.4307 mL2.8615 mL14.3074 mL
20 mM0.1431 mL0.7154 mL1.4307 mL7.1537 mL
Ethanol
1mg5mg10mg50mg
50 mM0.0572 mL0.2861 mL0.5723 mL2.8615 mL
100 mM0.0286 mL0.1431 mL0.2861 mL1.4307 mL

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