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Catalog No. TQ0174Cas No. 558447-26-0
Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC50 = 1 nM) and PBMCs (IC50 = 9 nM).
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Pack SizePrice/USDAvailabilityQuantity
1 mg$64In Stock
2 mg$93In Stock
5 mg$155In Stock
10 mg$232In Stock
25 mg$417In Stock
50 mg$619In Stock
100 mg$879In Stock
1 mL x 10 mM (in DMSO)$262In Stock
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Product Introduction

Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC50 = 1 nM) and PBMCs (IC50 = 9 nM).
In vitro
Mavorixafor (6.6 µM) significantly decreases the anchorage-dependent growth, migration, and matrigel invasion of the B88-SDF-1 cells [1]. Mavorixafor shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2) [2].
In vivo
AMD-070 (2 mg/kg, p.o.) markedly decreases the quantity of metastatic lung nodules in mice and reduces human Alu DNA expression without causing weight loss [1].
Cell Research
Cells are seeded on a 96-well plate at 5 × 10^3 cells/well in DMEM containing 10% FCS. Twenty-four hours later, the cells are treated with or without 2 µM AMD3100 or 6.6 µM AMD-070. After 24 or 48 h, the number of cells is quantified by an assay using MTT [2].
Animal Research
BALB/c nude mice are maintained under pathogen-free conditions. The experiments are initiated when the mice are 8 weeks of age. Briefly, the cells are inoculated into the blood vessels of nude mice (1× 10^6). These mice are sacrificed at day 49. The presence or absence of distant metastases is confirmed by hematoxylin and eosin (H&E) staining. For experimental chemotherapy, the mice are treated by the daily oral administration of 0.2 mL of saline for a vehicle or the same volume of AMD-070 (2 mg/kg) [2].
Chemical Properties
Molecular Weight349.47
Cas No.558447-26-0
Storage & Solubility Information
Storagestore under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 44 mg/mL (125.9 mM)
H2O: 7 mg/mL (20.03 mM)
DMSO: 17 mg/mL (48.64 mM)
Solution Preparation Table
1 mM2.8615 mL14.3074 mL28.6148 mL143.0738 mL
5 mM0.5723 mL2.8615 mL5.7230 mL28.6148 mL
10 mM0.2861 mL1.4307 mL2.8615 mL14.3074 mL
20 mM0.1431 mL0.7154 mL1.4307 mL7.1537 mL
50 mM0.0572 mL0.2861 mL0.5723 mL2.8615 mL
100 mM0.0286 mL0.1431 mL0.2861 mL1.4307 mL


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