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Mavorixafor

Catalog No. TQ0174 CAS 558447-26-0

Synonyms: AMD-070

Mavorixafor is an effective and selective antagonist of <a href="/target/CXCR" style="display: inline; color: #c13a36">CXCR</a>4, with an IC50 value of 13 nM against <a href="/target/CXCR" style="display: inline; color: #c13a36">CXCR</a>4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC50 = 1 nM) and PBMCs (IC50 = 9 nM).

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Mavorixafor, CAS 558447-26-0

Pack Size	Availability	Price/USD
2 mg	In stock	$ 113.00
5 mg	In stock	$ 163.00
10 mg	In stock	$ 232.00
25 mg	In stock	$ 417.00
50 mg	In stock	$ 677.00
100 mg	In stock	$ 1,217.00
200 mg	In stock	$ 2,117.00
500 mg	In stock	$ 3,987.00
1 mL * 10 mM (in DMSO)	In stock	$ 316.00

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Purity: 98%

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Description	Mavorixafor is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC50 = 1 nM) and PBMCs (IC50 = 9 nM).
Targets&IC50	HIV-1 (NL4.3 strain):1 nM (in MT-4 cells), HIV-1 (NL4.3 strain):3 nM (in MT-4 cells), HIV-1 (NL4.3 strain):9 nM (in PBMCs), 125I-SDF-CXCR4:13 nM
In vitro	Mavorixafor (6.6 µM) significantly decreases the anchorage-dependent growth, migration, and matrigel invasion of the B88-SDF-1 cells [1]. Mavorixafor shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2) [2].
In vivo	AMD-070 (2 mg/kg, p.o.) significantly reduces the number of metastatic lung nodules in mice, and lowers the expression of human Alu DNA in mice, without body weight loss [1].
Cell Research	Cells are seeded on a 96-well plate at 5 × 10^3 cells/well in DMEM containing 10% FCS. Twenty-four hours later, the cells are treated with or without 2 µM AMD3100 or 6.6 µM AMD-070. After 24 or 48 h, the number of cells is quantified by an assay using MTT [2].
Animal Research	BALB/c nude mice are maintained under pathogen-free conditions. The experiments are initiated when the mice are 8 weeks of age. Briefly, the cells are inoculated into the blood vessels of nude mice (1× 10^6). These mice are sacrificed at day 49. The presence or absence of distant metastases is confirmed by hematoxylin and eosin (H&E) staining. For experimental chemotherapy, the mice are treated by the daily oral administration of 0.2 mL of saline for a vehicle or the same volume of AMD-070 (2 mg/kg) [2].

Synonyms	AMD-070
Molecular Weight	349.47
Formula	C21H27N5
CAS No.	558447-26-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 44 mg/mL (125.9 mM)

H2O: 7 mg/mL (20.03 mM), warming

DMSO: 17 mg/mL (48.64 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Chow LN, et al. Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice. PLoS One. 2016 Mar 21;11(3):e0151765. 2. Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max ReFRAME Related Library Drug Repurposing Compound Library Pediatric Drug Library Bioactive Compound Library Inhibitor Library

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Keywords

Mavorixafor 558447-26-0 Autophagy GPCR/G Protein Immunology/Inflammation CXCR AMD 070 AMD-070 Human immunodeficiency virus AMD070 HIV inhibit CXC chemokine receptors Inhibitor inhibitor

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