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Lenacapavir

Catalog No. T11465 CAS 2189684-44-2

Synonyms: GS-6207

Lenacapavir (GS-6207) is a potent capsid-targeting inhibitor of HIV replication. Lenacapavir shows anti-HIV activity with an EC50 of 100 pM in MT-4 cells.

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Lenacapavir, CAS 2189684-44-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 333.00
5 mg	In stock	$ 690.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,670.00
50 mg	In stock	$ 2,250.00
100 mg	In stock	$ 2,970.00

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Purity: 100.00%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lenacapavir (GS-6207) is a potent capsid-targeting inhibitor of HIV replication. Lenacapavir shows anti-HIV activity with an EC50 of 100 pM in MT-4 cells.
Targets&IC50	Anti-HIV:100 pM (EC50), MT-4 cells:100 pM (EC50)
In vitro	Lenacapavir displays a mean EC50 of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells. Lenacapavir shows sub-nanomolar potency in target cells with EC50 of 23 pM, in a full-cycle assay with EC50 of 25 pM and in producer cells with EC50 of 439 pM[2].

Synonyms	GS-6207
Molecular Weight	968.28
Formula	C39H32ClF10N7O5S2
CAS No.	2189684-44-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 195 mg/mL (201.39 mM), Sonication is recommended.

References and Literature

1. John O Link, et al. Clinical targeting of HIV capsid protein with a long-acting small molecule. Nature. 2020 Jul 1. 2. Singh K, et al. GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds. Front Microbiol. 2019 Jun 20;10:1227.

Related compound libraries

This product is contained In the following compound libraries：

EMA Approved Drug Library Inhibitor Library Drug Repurposing Compound Library ReFRAME Related Library Bioactive Compound Library Orally Active Compound Library Anti-Viral Compound Library FDA-Approved Drug Library Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library

Related Products

Related compounds with same targets

Vitexilactone Andropanolide HIV-1 Inhibitor 18A Vicriviroc maleate Doravirine HIV-1 inhibitor-53 HIV-1 Nef-IN-1 Islatravir

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lenacapavir 2189684-44-2 Microbiology/Virology Others Proteases/Proteasome HIV Protease MT-4 Inhibitor antiretroviral GS-6207 inhibit GS6207 capsid GS 6207 Human immunodeficiency virus HIV HIV-1 PBMCs inhibitor

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